Source: Annual Congress 2008 - Lung and bone marrow transplantation: miscellaneous
Disease area: Respiratory infections

Abstract

Mycobacterium abscessus is an ubiquitous, rapidly growing mycobacterium. It is a potential pathogen, especially for immunosuppressed patients (ISP). OBJECTIVE: To present the experience of a tertiary hospital, in the systematic detection of this microorganism, focusing mainly on respiratory infections in ISP. METHODS: Period analyzed: January 1997-December 2006. Data of culture and in vitro susceptibility testing of samples were obtained from the Microbiology Department database. Criteria for the classification of the isolates: a) causing disease (D): direct visualization, different methods of culture, abundant growth, repeated samples and medical history compatible with disease; b) contaminants (C): not direct visualization, delayed growth, unique colony or method; c) colonization (CL): undetermined criteria. RESULTS: Isolation of M. abscessus in 45 patients, 69% in the last 5 years: 20 D: 4 children and 16 adults: 4 (20%) disseminated: (1 astrocitoma, 1 lung transplant (LT)+ cystic fibrosis (CF), 1 sarcoma and 1 osteomyelitis); 16 (80%) localized: 10 respiratory (2 AIDS, 3 CF, 1 LT+CF, 1 LT+COPD, 1 asthma and 2 lung cancer) and 3 catheter-related; 12 C (11 respiratory; 1 urine); 13 CL, all respiratory: 3 (LT). Clinical evolution with treatment has been favourable in all cases. CONCLUSION: 1) M. abscessus isolation has increased in the last five years.2) The cause might be due to the increased number of immunosuppressed patients and/or pulmonary chronic diseases. 3) In this population it is convenient to search systematically for this microorganism. 4) Isolates were mainly from respiratory samples (78%). 5) Favourable outcome depended on early diagnosis and adjusted treatment.

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Citations should be made in the following way:
P. Morales, M. Santos, A. Gil, A. Navarro, M. Gobernado (Valencia, Spain). Mycobacterium abscessus respiratory infection: importance in immunosuppressed patients. Eur Respir J 2008; 32: Suppl. 52, 1632

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