Source: Annual Congress 2008 - Mechanisms of respiratory infections: interaction between the pathogen and the host
Disease area: Airway diseases, Respiratory infections

Abstract

Aim: To investigate the specific blood immune response to Haemophilus in patients with stable COPD.
Methods : We collected clinical information, sputum and serum from 13 COPD patients in a 18 months PILOT cohort study with follow-up visits scheduled every 9 months. Serum antibodies to Haemophilus were detected with whole bacterial cell ELISA. Data of IgA, IgG and IgM were corrected with a pool of healthy controls serum samples and were analyzed according to the isolated microorganisms and their changes between visits.
Results : The results of IgA, IgG and IgM levels were 1.40±0.35, 1.25±0.23 and 1.07±0.25 at baseline visit. We observed a correlation IgG:IgA (Pearson correlation coefficient [r], 0.443; p<0.05) and IgG:IgM ([r], 0.541; p<0.01) levels. No differences in the IgG, IgA or IgM levels of Haemophilus-specific response were found according to the Haemophilus species isolated in each visit. Nonetheless, in patients with a positive culture for H. influenzae, IgM response was correlated with IgA (Pearson c.c. [r], 0.541; p<0.05) and IgG ([r], 0.791; p<0.01) whereas, when H. parainfluenzae was the microorganism isolated, the IgA response was correlated with IgG (Pearson c.c. [r], 0.874; p<0.01).
Follow-up study: When the same PFGE pattern was isolated between 2 visits, levels of Haemophilus-specific IgA (t test, p=0.027) and IgM (p>0.05) were increased, but not IgG levels that remained stable. Moreover, when no Haemophilus species were isolated in the follow-up visit, levels of IgG and IgM decreased, but not IgA levels.
Conclusions : Persistent bronchial colonization by Haemophilus in stable COPD patients is associated with a specific blood immune response mainly IgA and IgM mediated
Funded by FIS06/0684.

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Citations should be made in the following way:
L. Millares, M. Garcia-Nuñez, A. Marin, M. Sabria, J. Morera, S. Alberti, E. Monso (Badalona (Barcelona), Spain). Specific blood immune response to haemophilus in stable COPD patients. Eur Respir J 2008; 32: Suppl. 52, 2282

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