Alveolar hypoxia induces generation of IL-18 in mice. IL-18 reduces phosphorylation of the calcium handling protein phospholamban in cardiomyocytes

K. O. Larsen, B. Lygren, I. Sjaastad, K. A. Krobert, G. Florholmen, K. Arnkvaern, F. O. Levy, O. H. Skjonsberg, K. Tasken, G. Christensen (Oslo, Norway)

Source: Annual Congress 2008 - Pathophysiology of pulmonary hypertension
Session: Pathophysiology of pulmonary hypertension
Session type: E-Communication Session
Number: 283
Disease area: Pulmonary vascular diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. O. Larsen, B. Lygren, I. Sjaastad, K. A. Krobert, G. Florholmen, K. Arnkvaern, F. O. Levy, O. H. Skjonsberg, K. Tasken, G. Christensen (Oslo, Norway). Alveolar hypoxia induces generation of IL-18 in mice. IL-18 reduces phosphorylation of the calcium handling protein phospholamban in cardiomyocytes. Eur Respir J 2008; 32: Suppl. 52, 283

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Hypoxia induced cardiac dysfunction maybe caused by increased IL-18 levels leading to dephosphorylation of Ca2+ handling proteins
Source: Annual Congress 2007 - Novel mediators of cellular pathology
Year: 2007


N-Acetylcysteine inhibits eotaxin and MCP-1 release in human airway smooth muscle cells in vitro through the inhibition of ROS production, resulting in a decrease of p38 MAP kinase activation
Source: Eur Respir J 2002; 20: Suppl. 38, 170s
Year: 2002

Inhibitory effects of the IL-6 receptor superantagonist SANT7 on MAP kinase phosphorylation and cell proliferation induced by IL-6 and TGF-beta1 in human lung fibroblasts
Source: Annual Congress 2008 - Clinical aspects of interstitial lung disease
Year: 2008

Inhibition of ER stress suppresses IL-13 induced airway epithelial remodeling
Source: International Congress 2019 – COPD, asthma and rhinitis: from cellular mechanisms to patients’ clinical responses
Year: 2019

Effects of endothelin-1 on MAPK activation, IL-6 production and cell proliferation in normal human lung fibroblasts
Source: Eur Respir J 2004; 24: Suppl. 48, 454s
Year: 2004

Involvement of protein kinase A (PKA) in the IL-1β induced MCP-1 production in human airway smooth muscle cells
Source: Eur Respir J 2001; 18: Suppl. 33, 353s
Year: 2001

Chronic hypoxia alters the phosphorylation of phospholamban in mouse hearts
Source: Eur Respir J 2005; 26: Suppl. 49, 353s
Year: 2005

Hypoxia induces IL-18 and neutrophil influx in lung parenchyma possibly mediated by MIP-2
Source: Annual Congress 2012 - The many roads to lung injury
Year: 2012

Effects of budesonide on p38 MAPK activation, apoptosis and IL-8 secretion, induced by TNF-alpha and Haemophilus influenzae in human bronchial epithelial cells
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Interleukin-17 enhances epithelial IL-6 production solely by stabilizing IL-6 mRNA, which is reversed by microRNA16
Source: Eur Respir J 2007; 30: Suppl. 51, 212s
Year: 2007

Inhibition of P38 kinase does not reduce production of TNF-alpha from airway cells in COPD
Source: Annual Congress 2007 - Epithelial networks in the airways
Year: 2007


Autocrine secretion of bradykinin prevents alveolar type II cells from mechanical stretch-induced apoptosis by activation – role of PI3K and Akt
Source: Annual Congress 2008 - Border patrol: the alveolar barrier in lung injury
Year: 2008


Effects of HSP70 induction on IL-6 production from murine alveolar epithelial cells pre-treated with endotoxine after subsequent endotoxin challenge
Source: Eur Respir J 2005; 26: Suppl. 49, 346s
Year: 2005

Inhibition of chloride channel activity by BMP-2 in lung fibroblasts opposes profibrotic action of endothelin-1
Source: Annual Congress 2010 - Pathobiology of pulmonary hypertension
Year: 2010

PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model
Source: Annual Congress 2011 - Animal models of airway inflammation
Year: 2011

Protein kinase C and mitochondrial signaling mediate PM10-induced ROS and TGF-β expression in the bronchial epithelial cells
Source: Eur Respir J 2007; 30: Suppl. 51, 574s
Year: 2007

α1-Antitrypsin (α1-AT) instillation decreases neutrophil influx and increases cytokine levels in the BAL of LPS-treated mice
Source: Annual Congress 2008 - Understanding allergic airway inflammation with the help of animal models
Year: 2008

RAGE deficiency improves alveolar fluid clearance in LPS-induced acute lung injury by preventing downregulation of Na-K-ATPase and ENaC
Source: International Congress 2017 – Anti-inflammatory and pro-repair mediators in acute lung injury
Year: 2017


IL-4 induces Th2 cells to resist the IL-27 counterregulation by downregulating STAT1 and STAT2 phosphorylation
Source: Annual Congress 2012 - Asthma: mechanisms of airway inflammation
Year: 2012

Inhibition of histone acetyltransferases attenuates cytokine and LPS-induced up-regulation of arginase in rat alveolar macrophages
Source: Eur Respir J 2006; 28: Suppl. 50, 662s
Year: 2006