Source: Annual Congress 2008 - Lung and bone marrow transplantation: miscellaneous

Abstract

After lung transplantation (LTx), exercise capacity frequently remains limited (peak VO2 between 40 and 60% of predicted values), even if pulmonary function returns to normal or near-normal. The aim of this study was to examine the effets of underlying disease on exercice tolrance post-LTx.
We retrospectively review the case of 33 subjects who received LTx between 2000 and 2007. Sixteen patients suffered from cystic fibrosis (CF) and 17 suffered from others diseases (non-CF). Lung function did not differ between groups, even if CF patients had bilateral LTx. Symptom-limited exercise testing reveal that most of patients stopped because of leg fatigue (two subjects stopped because of dyspnea). Exercise capacity, expressed by symptom-limited oxygen uptake, is significantly lower in the non-CF group (47,7 +/- 11,6 % predicted) when compared with the CF group (63,1 +/- 12,4 % predicted, p<0,05). The same was noted for work capacity (watts). Ventilatory fators was not responsible for the exercise limitation, as all patients but one showed a preserved ventilatory reserve at the end of the test. No significant oxygen desaturation was noted. Exercise capacity, when expressed according to predicted values, was not significantly influenced by age or sex.
Conclusion : CF patients who received LTx showed decreased exercise capacity, but this latter is substantially lower in the non-CF group. Factors like medications, mean daily dose of prednisolone, prolonged hospitalisation after LTx and deconditioning will be explored.

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Citations should be made in the following way:
N. Germain-Lacroix, C. Poirier, A. Yannopoulos, C. Poirier (Montreal, Canada). Exercise capacity following lung transplantation in cystic fibrosis patients. Eur Respir J 2008; 32: Suppl. 52, 1637

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Ghyslain Lauzon - 07.10.2008 13:06
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