Intermittent hypoxic training increases exercise tolerance in chronic obstructive pulmonary disease
M. Burtscher, H. Thomas, T. Linser, H. Gatterer, M. Faulhaber, E. Pocecco, I. Ehrenbourg, W. Domej, E. Tkatchouk, L. Bernardi (Pavia, Italy; Innsruck, Graz, Austria; Moscow, Russian Federation)
Source: Annual Congress 2008 - Physiological response to exercise performance
Session: Physiological response to exercise performance
Session type: E-Communication Session
Number: 3296
Disease area: Airway diseases
Abstract Association between modifications in disease markers and health status (HS) are unclear. The aim of this study was to verify predictors of HS modification in COPD patients over three years. Eight-nine consecutive COPD patients (67% male, age= 67±9 y, FEV1 = 58±23%) underwent following the evaluations: body composition, six-minute walk distance (6MWD), Modified Medical Research Council scale(MMRC) and Saint George‘s Respiratory Questionnaire (SGRQ). The baseline variables age and gender and the difference between baseline and after 3 years measurements (Δ) for forced expiratory volume in the first second (ΔFEV1 ), fat-free mass (ΔFFM), dypsnea perception (ΔMMRC), exercise tolerance (Δ6MWD) and number of exacerbation were included in a multiple linear regression analysis where the total SGRQ score after 3 years was the dependent variable. Logistic regression was also performed to evaluate the influence of clinically significant increase in 6MWD (> 54m), decrease in MMRC (< 1), gender and number of exacerbation on total SGRQ stability/improvement (< 4%) or deterioration (> 4%). Total SGRQ score (41±19% vs 44±18%; p=0.01) deteriorated during the follow-up and the number of exacerbation was the only variable selected as predictor of the total SGRQ [OR 3.34 (95% CI 1.25-5.42)] after three years. Clinically significant increase in 6MWD [OR 1.00 (95% CI 1.00-1.00) was the best predictor for improvement or stability of the SGRQ and exacerbation occurrence [OR 0.94 (95% CI 0.90-0.99)] was the best predictor of deterioration in health status. In summary, control of exacerbations and measures to improve exercise tolerance may contibute to maintenance of health status in COPD patients.
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M. Burtscher, H. Thomas, T. Linser, H. Gatterer, M. Faulhaber, E. Pocecco, I. Ehrenbourg, W. Domej, E. Tkatchouk, L. Bernardi (Pavia, Italy; Innsruck, Graz, Austria; Moscow, Russian Federation). Intermittent hypoxic training increases exercise tolerance in chronic obstructive pulmonary disease. Eur Respir J 2008; 32: Suppl. 52, 3296
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