Source: Annual Congress 2008 - Lung and bone marrow transplantation: miscellaneous
Disease area: Interstitial lung diseases

Abstract

Objective: To test the behavior of 8 mm diameter ringed goretex prosthesis in cervical trachea.
Methods: 13 rabits were operated on as follows: Group I (n=6): 10 rings cervical trachea segment autotransplantation.Group II (n=7): 10 rings cervical trachea segment replacement with 8 mm diameter ringed goretex. All anastomosis were performed with 7-0 running prolene.1 rabit was euthanized on 7th post-op day, 1 rabit was euthanized on 14th post-op day. Tracheoscopy was performed imediately after surgery, every week for the 1st post-op month, every 2 weeks the next months. Microscopy: HE, Mason‘s stains. Statistical analysis: ANOVA, X2.
Results: 13 rabits survived the surgical procedure.Group I: 3 rabits presented mild necrosis,they were euthanized on 4th post-op week. 3 spontaneosly revascularized autograft are alive on 20th post-op week. Group II: 1 rabit was euthanized on 7th post-op day, 1 rabit was euthanized on 14th post-op day.2 rabits died on 7th post-op week, 1 died on 10th post-op week, 1 died on 11th post-op week. These 4 rabits died due to heavy mucus overproduction, with 10% tracheo-prosthesis junction stenosis. The prosthesis is covered in the outside with fibrosis. Tracheo-prosthetic junction showed mild inflammatory and fibrotic stenosis.1 is alive on 17th post-op week, with 25% stenosis and 30% tracheo-prosthetic junction stenosis.
Conclusions: The ringed goretex prosthesis produces mild inflammatory and fibrotic reaction on tracheo-prosthetic junction. There is no anastomotic necrosis, nor fistula formation.This ringed goretex prosthesis should be tested in a higher specie. We do not know why 3 rabits with 10 rings autotransplanted tracheal segment were spontaneosly revascularized.

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J. A. Santibanez, J. R. Olmos, R. Jasso, J. Villalba, A. Rey, D. Perez, A. Sotres, M. Gaxiola, M. Baltazares, S. Flores (Mexico, D.F., Mexico). Trachea replacement with 8 mm ringed goretex prosthesis in the rabit. Eur Respir J 2008; 32: Suppl. 52, 1629

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