Source: Annual Congress 2008 - Diagnosis of tuberculosis: problems and perspectives
Disease area: Respiratory infections

Abstract

Background Reizenstein described in 1975 the reactive haematologyc syndrome (RHS) in the chronic diseases. A sine qua non condition of this syndrome is inflammatory anemia (IA). Associated abnormalities are thrombocytosis, leucocytosis, hiperfibrinogenemia, troubles of coagulation, decrease of zync and cholesterol levels.
Aims To demonstrate: the existence of this syndrome in active pulmonary tuberculosis (PTB); its impact on evolution of pulmonary tuberculosis; the importance of diagnosis of RHS in PTB for the treatment.
Methods 135 consecutive patients with active PTB and anemia were investigated before and after one, three and six months of antiTB treatment.
Results Anemia was inflammatory (hypofferemia with normal or increased ferrum store) in 105, iron deficient in 18 and mixt in 12 cases. Thrombocytemia was present in 37, leucocytosis in 57 and hypocholesterolemia in 17 cases into the group with IA. During the anti-TB treatment anemia was cured (average 60 days) in 88 out of 105 patients with IA without iron intake. The number of thrombocytes, leucocytes and fibrinogen levels got normal, in this order, in the first month of this treatment. The evolution of 17 patients with PTB and RHS was to the chronic PTB.
Conclusions PTB with evolution >1,5 month can determine RHS. Investigation of ferrum deposit must be done in PTB associated with anemia. A correct diagnosis of RHS avoids unjust therapeutical decisions. The evaluation of abnormalities of RHS can estimate the efficiency of antiTB treatment, the prognostic and the evolution of PTB. Persistent RHS, despite a good evolution of PTB, must extent investigation for another disease.

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Citations should be made in the following way:
E. Popa (Iasi, Romania). Reactive haematologyc syndrome in active pulmonary tuberculosis. Eur Respir J 2008; 32: Suppl. 52, 2380

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