Stimulation of CFTR-dependent chloride secretion by roflumilast

N. Pedemonte, L. Galietta (Genova, Italy)

Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD II
Session: Novel experimental approaches to understanding asthma and COPD II
Session type: Thematic Poster Session
Number: 3672
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
N. Pedemonte, L. Galietta (Genova, Italy). Stimulation of CFTR-dependent chloride secretion by roflumilast. Eur Respir J 2008; 32: Suppl. 52, 3672

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
A long-acting β2-adrenergic receptor agonist increases cAMP-induced chloride secretion in human airway epithelial cells
Source: Eur Respir J 2004; 24: Suppl. 48, 555s
Year: 2004

Na+-K+-2Cl- co-transport inhibition and bronchoprotective effect of inhaled furosemide in asthmatics
Source: Eur Respir J 2002; 20: Suppl. 38, 190s
Year: 2002

PPARγ agonists modulate transepithelial anion secretion in human airway epithelial cells
Source: Eur Respir J 2005; 26: Suppl. 49, 483s
Year: 2005

Effect of n-butyldeoxynojirimycin on chloride efflux from CF airway epithelial cells
Source: Annual Congress 2009 - Cystic fibrosis: advances in clinical research
Year: 2009

Inhibition of the airway response to mannitol with either eformoterol or sodium cromoglycate (SCG) does not alter leukotriene release in asthmatic subjects
Source: Eur Respir J 2004; 24: Suppl. 48, 443s
Year: 2004

Azithromycin increases chloride efflux from airway epithelial cells
Source: Annual Congress 2008 - Recent advances in the treatment and pathogenesis of pulmonary diseases
Year: 2008

Flagellin potentiates the Ca2+-dependent electrolytes secretion from airway submucosal gland in a TLR4-independent, TLR5-dependent and cGK-dependent manner
Source: Annual Congress 2012 - Cellular signalling mechanisms in the airways
Year: 2012

Inhibition of chloride channel activity by BMP-2 in lung fibroblasts opposes profibrotic action of endothelin-1
Source: Annual Congress 2010 - Pathobiology of pulmonary hypertension
Year: 2010

Nasal transepithelial potential difference does not reflect beta2-adrenergic stimulation of transepithelial sodium transport-driven alveolar fluid clearance in mice
Source: Eur Respir J 2001; 18: Suppl. 33, 257s
Year: 2001

Expression of HCLCA1, a calcium activated chloride channel upregulated in the airway of asthmatic patients
Source: Eur Respir J 2002; 20: Suppl. 38, 572s
Year: 2002

Sodium sulfite enhances rhinovirus-induced chemokine production in airway epithelial cells
Source: Annual Congress 2012 - Airway infections in children: from risk factors to treatment
Year: 2012

Synergistic inhibition of salmeterol with fluticasone propionate or rolipram on stimulated eosinophil binding of β2-integrin to ICAM-1 and cytosolic gIV-phospholipase A2 activation
Source: Eur Respir J 2003; 22: Suppl. 45, 455s
Year: 2003

Effects of glucocorticosteroids and antimicrobial drugs on inhibition of IL-1β- and PDBu-induced IL-8 release in the presence of pyocyanin in bronchial epithelial cell line
Source: Eur Respir J 2005; 26: Suppl. 49, 99s
Year: 2005

Sodium cromoglycate inhibits release of mast cell mediators and bronchoconstriction following hyperpnea in athletes
Source: Annual Congress 2010 - Pharmacological modulation of biomarkers and management
Year: 2010

Extracellular and intracellular magnesium before and after methacholine-induced bronchoconstriction in asthmatics
Source: Eur Respir J 2002; 20: Suppl. 38, 504s
Year: 2002

The Ca2+-activated K+ channel iKCA1 enhances Ca2+ influx and degranulation in human lung mast cells
Source: Eur Respir J 2004; 24: Suppl. 48, 453s
Year: 2004

Mechanisms of acetylcholine-induced release of proinflammatory extracellular vesicles by endothelial cells and inhibitory effects of tiotropium
Source: International Congress 2019 – Identification of new targets and therapeutic strategies for lung disease
Year: 2019


LSC 2011 Abstract: Combined nasal exposure to sodium hypochlorite and ovalbumin induces airway hyperreactivity in mice through activation of the TRPA1 channel and mast cells
Source: Annual Congress 2011 - Environmental exposure and disease mechanisms
Year: 2011


Inhibition of IL-8 and RANTES release from cultured human airway smooth muscle cells by fluticasone and budesonide
Source: Eur Respir J 2002; 20: Suppl. 38, 384s
Year: 2002

Inhaled CCR1 antagonist AZD4818 reduces leucocyte influx in the rat lipopolysaccharide (LPS) lung inflammation model
Source: Annual Congress 2009 - Preclinical models in drug development
Year: 2009