Source: Annual Congress 2008 - Physiological response to exercise performance
Disease area: Airway diseases

Abstract

Aim: The purpose of this study was to examine the dyspnea during the six-minute walk test (6MWT) in patients with chronic obstructive pulmonary disease.
Subjects and Methods: Fourteen subjects (14 male, age 75.6 ± 7.2 years old, with FEV₁ 66.4 ± 19.3 % of predicted) took part in the study. Throughout the 6MWT, oxygen uptake, carbon dioxide production, minute ventilation, and heart rate were measured using a portable cardiopulmonary exercise system (MetaMax 3B, Cortex, Germany). Dyspnea and oxygen saturation were recorded at the end of each minute during the 6MWT. Dyspnea was measured using the Borg 0-10 dyspnea scale. Inspiratory capacity (IC) was measured at every two minute during the 6MWT.
Results: This study showed that the distance walked in the 6MWT was 521.0 ± 98.6 m, the Borg dyspnea scale at the end of the 6MWT was 3.6 ± 1.8, and peak oxygen uptake was 13.41 ± 2.54 ml/min/kg. The value of oxygen saturation showed 89.8 ± 5.6 after 6MWT. The value of IC was 1.34 ± 0.36 L before 6MWT, and 1.21 ± 0.29 L after 6MWT. The value of IC was significantly lower at the end of 6MWT compared to that before 6MWT (p<0.05). The degree of dyspnea significantly increased with time, and the value of oxygen uptake showed a tendency to become higher during 6MWT.
Conclusions: This study suggested that the dyspnea during 6MWT was caused by not only the dynamic hyperinflation but also the sense of respiratory effort.

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M. Satake, T. Shioya, H. Takahashi, K. Sugawara, C. Kasai, N. Kiyokawa, T. Watanabe, S. Fujii, T. Shiki, M. Honma (Akita, Japan). Dyspnea during 6MWT in stable patients with chronic obstructive pulmonary disease. Eur Respir J 2008; 32: Suppl. 52, 3293

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