Acute asthma characteristics and the risk of subsequent admissions in children
O. Savenije, A. Martin, G. Zhang, J. Bizzintino, K. Rueter, G. Geelhoed, J. Goldblatt, P. Le Souef, I. Laing (Groningen, Netherlands; Perth, Australia)
Source: Annual Congress 2008 - Treatment and outcome of childhood asthma: new perspectives
Disease area: Airway diseases
Abstract Introduction: The causes of variations in asthma exacerbation patterns in children are unclear. Methods: Children were studied on presentation with acute asthma (n=100) to a tertiary hospital emergency department and followed up twice when well: at least 6wks (FU1) and >12mths later (FU2). During the acute episode, asthma severity score (ASS), total IgE and asthma pattern were evaluated. Total IgE was measured again at FU1. At FU2, the number of admissions since recruitment was determined using a parental questionnaire. Poisson regression analyses were employed to estimate the incidence risk ratios (IRR) of admission for each potential risk factor. Results: Mean age 6.7 yrs (95% CI:6.0-7.5) at presentation, FU2 mean 3.7 (95% CI:3.5-3.9) yrs later, 65% male. Further admissions: 0.4 (95%CI:0.23-0.56) first 12 months (#adm12) and 1.2 (95%CI:0.7-1.7) per year (#adm/yr) overall. Females had an increased risk ratio (IRR) of 3.94 (95% CI:2.02-7.67; p<0.001) for #adm12 and 4.93 (95% CI:2.36-1031; p<0.001) for #adm/yr. Younger children had lower IRR for #adm/yr (0.88; 95% CI:0.80-0.98; p=0.019), but not #adm12 (0.95; 95% CI:0.88-1.03; p=0.24). Recruitment ASS and total IgE were not associated with #adm12 or #adm/yr. Total IgE levels (n=38) at FU1 were inversely correlated with #adm/yr (r2=-0.33, p=0.04). Those with persistent asthma prior to recruitment had an increased risk of #adm12 (IRR: 3.44; 95% CI: 1.53-7.75; p=0.003). Conclusions: The severity of attack and atopy during an acute episode may not be related to the frequency of exacerbations in children. Gender and age are risk factors for frequent severe asthma attacks.
Rating:
You must login to grade this presentation.
Share or cite this content
Citations should be made in the following way:
O. Savenije, A. Martin, G. Zhang, J. Bizzintino, K. Rueter, G. Geelhoed, J. Goldblatt, P. Le Souef, I. Laing (Groningen, Netherlands; Perth, Australia). Acute asthma characteristics and the risk of subsequent admissions in children. Eur Respir J 2008; 32: Suppl. 52, 4595
You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.
Member's Comments
Related content which might interest you:
Related content which might interest you:
Prevalence rate and risk factors for hospital readmissions for asthma in children and adolescents in a tropical setting Source: Eur Respir J 2002; 20: Suppl. 38, 535s Year: 2002
Risk factors associated with repeated hospitalization for asthma attacks in children Source: Eur Respir J 2004; 24: Suppl. 48, 389s Year: 2004
Factors related to hospital admissions in children with asthma Source: Eur Respir J 2004; 24: Suppl. 48, 17s Year: 2004
Risk factors for hospitalization of an acute exacerbation of COPD patients Source: Eur Respir J 2006; 28: Suppl. 50, 177s Year: 2006
Are we routinely using severity assessment in hospital admissions with acute severe asthma? Source: Annual Congress 2008 - Severe asthma: a heterogeneous clinical entity Year: 2008
Risk factors for asthma exacerbation in children and adolescents Source: International Congress 2018 – The bad and the ugly in paediatric asthma: comorbidities and exacerbations Year: 2018
Risk factors for severe asthma attacks in Romanian children Source: Eur Respir J 2006; 28: Suppl. 50, 253s Year: 2006
Risk factors for severe exacerbations in a real-life population of adults with severe refractory asthma Source: International Congress 2017 – Many faces of asthma and allergies Year: 2017
Risk factors associated with hospitalized asthma patients Source: Eur Respir J 2001; 18: Suppl. 33, 51s Year: 2001
Risk factors for wheezing and allergy in preschool children (PSC) after admission for acute bronchiolitis Source: Annual Congress 2011 - Innate and exogenous factors in childhood respiratory infection Year: 2011
Risk factors for severe asthma among adults with asthma Source: Virtual Congress 2020 – Diagnosis and management of asthma Year: 2020
Incidence and risk factors of acute exacerbations of COPD in Italy Source: Eur Respir J 2001; 18: Suppl. 33, 152s Year: 2001
Clinical asthma score as a predictor for hospital admissions and duration of stay in children presenting with acute asthma to a paediatric emergency department Source: Annual Congress 2013 –Uncontrolled and severe asthma in children Year: 2013
Effect of omalizumab on the risk of hospitalisation in patients with uncontrolled severe asthma in real-life. The PAX-LASER cohort Source: Annual Congress 2010 - Aspects of severe asthma Year: 2010
Role of a prolonged inpatient admission when evaluating children with problematic severe asthma Source: Eur Respir J, 51 (2) 1701061; 10.1183/13993003.01061-2017 Year: 2018
Trends in the lifetime risk of COPD exacerbation requiring hospitalisation Source: Eur Respir J 2013; 42: 964-971 Year: 2013
Risk factors of near fatal asthma in elderly patients Source: Eur Respir J 2001; 18: Suppl. 33, 52s Year: 2001
Chronic respiratory diseases are predictors of severe outcome in COVID-19 hospitalised patients: a nationwide study Source: Eur Respir J, 58 (6) 2004474; 10.1183/13993003.04474-2020 Year: 2021
Is anemia associated with readmission risk in severe acute exacerbation of COPD: Preliminary results from a naturalistic cohort Source: Virtual Congress 2020 – Clinical data and COPD management Year: 2020
Predisposing factors for hospital admission due to acute respiratory failure in non smoker women Source: Eur Respir J 2004; 24: Suppl. 48, 56s Year: 2004