Source: Annual Congress 2008 - Physiological response to exercise performance
Disease area: Airway diseases

Abstract

Introduction
Quadriceps muscle weakness is a common problem in COPD. High-intensity isokinetic quadriceps resistance training can restore muscle mass and strength in immobilised healthy adults. We explored the effects of this training regime in a group of COPD patients.
Methods
14 COPD subjects [mean(SD) age 67.2(11.3) years, FEV₁ 49.2(13.0) % predicted, BMI 27.6(5.2), 9 males] underwent a supervised programme of bilateral quadriceps resistance training on an isokinetic dynamometer(Cybex). Training consisted of 5 sets of 30 maximal knee extensions at 180°/s, thrice weekly for 8 weeks. Incremental cycle ergometry, isometric and isokinetic strength of the dominant quadriceps, and quadriceps muscle mass by DEXA, were measured at baseline and after 8 weeks. Prior familiarisation to both the cycle ergometer and cybex was done at baseline.
Results
Training led to significant improvements in peak VO₂, peak cycling workload(Wpeak), quadriceps strength and mass(Table 1)

Table 1

	Pre	Post	Mean Change
VO2 peak(ml/kg/min)	14.6(5.3)	18.9((7.6)	4.3(6.0)*
Wpeak(Watts)	61.4(27.6)	71.2(25.7)	9.7(14.5)*
Isometric Strength(Nm)	110.9(47.4)	126.3(46.4)	15.4(13.1)***
Isokinetic Strength(Nm)	77.7(36.9)	93.1(40.6)	15.3(12.0)***
Quadriceps Muscle Mass(Kg)	4.3(1.0)	4.4(1.0)	0.1(0.1)**

Values expressed as means(SD). ***p≤0.001, **p<0.01, *p<0.05

There was also a significant correlation between percentage changes in Wpeak and muscle strength(isometric p=0.032, r=0.57; isokinetic p=0.031, r=0.57)
Conclusions
Our data suggests that a programme of high-intensity isokinetic quadriceps resistance training in COPD patients can produce significant improvements in quadriceps muscle mass, strength and maximal exercise performance.

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Citations should be made in the following way:
M. Menon, L. Houchen, S. Singh, M. Morgan, M. Steiner (Leicester, Coventry, United Kingdom). Effects of high-intensity isokinetic quadriceps resistance training in COPD. Eur Respir J 2008; 32: Suppl. 52, 3299

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