Aminoguanidine attenuates bleomycin-induced pulmonary fibrosis in rats through inhibition of heat shock protein 47 and TGF-β1 expression

L. Chen, F. Q. Wen, T. Wang, X. Wang, D. S. Liu (Chengdu, Sichuan, China)

Source: Annual Congress 2008 - Animal models of pulmonary fibrosis: mechanisms and therapies
Session: Animal models of pulmonary fibrosis: mechanisms and therapies
Session type: Thematic Poster Session
Number: 713
Disease area: Interstitial lung diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
L. Chen, F. Q. Wen, T. Wang, X. Wang, D. S. Liu (Chengdu, Sichuan, China). Aminoguanidine attenuates bleomycin-induced pulmonary fibrosis in rats through inhibition of heat shock protein 47 and TGF-β1 expression. Eur Respir J 2008; 32: Suppl. 52, 713

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Heat shock protein 90 inhibitors block pulmonary fibrosis and dysfunction in HCl-exposed mice.
Source: International Congress 2017 – Novel pro- and anti-fibrotic mechanisms in pulmonary fibrosis
Year: 2017


Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis
Source: Eur Respir J 2004; 24: 57-65
Year: 2004



Dexamethasone inhibits surfactant degradation during bleomycin-induced lung injury in rats
Source: Eur Respir J 2006; 28: Suppl. 50, 855s
Year: 2006

Rho-kinase inhibitor ameliorates bleomycin-induced chronic lung injury in neonatal rats
Source: Annual Congress 2011 - Issues in paediatric and neonatal intensive care
Year: 2011

Metformin attenuates bleomycin-induced pulmonary fibrosis in mice via IGF-1 suppression
Source: International Congress 2018 – Novel insights in the basic and translational research on idiopathic interstitial pneumonias
Year: 2018

Effect of NF-?B inhibitor IMD-1041 on BLM-induced pulmonary fibrosis in mice
Source: International Congress 2017 – Lung fibrosis: basic science
Year: 2017


The effect of curcumin on bleomycin-induced pulmonary fibrosis in rats
Source: Eur Respir J 2006; 28: Suppl. 50, 827s
Year: 2006

The role of osteopontin in the pulmonary fibrosis caused by acute lung injury induced by lipopolysaccharide in rats
Source: Annual Congress 2011 - Acute respiratory failure
Year: 2011

The effect of dexamethasone on the pulmonary fibrosis of acute lung injury induced by lipopolysaccharide in rats
Source: Annual Congress 2007 - Respiratory pathophysiology
Year: 2007


PD98059 attenuates the development of bleomycin-induced lung injury and fibrosis
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Expression of TGF-β and TGFβ receptors in bleomycin-induced pulmonary fibrosis of rats
Source: Eur Respir J 2002; 20: Suppl. 38, 312s
Year: 2002

Overexpression of ISCU can extenuate mitochondrial damage, reduce EMT and bleomycin-induced pulmonary fibrosis
Source: Virtual Congress 2020 – Mechanistic insight into lung injury and repair
Year: 2020

Effect of fasudil on the bleomycin-induced pulmonary fibrosis and hypertension in mice
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms
Year: 2012



The influence of dexamethasone on the proliferation and apoptosis of pulmonary inflammatory cells in bleomycin-induced pulmonary fibrosis in rats
Source: Eur Respir J 2002; 20: Suppl. 38, 487s
Year: 2002

Ghrelin protects against bleomycin-induced pulmonary fibrosis in mice
Source: International Congress 2017 – Lung fibrosis: basic science
Year: 2017


Thrombin-activatable fibrinolysis inhibitor deficiency attenuates bleomycin-induced pulmonary fibrosis
Source: Eur Respir J 2005; 26: Suppl. 49, 461s
Year: 2005

Effects of elastase inhibitor on the epithelial cell apoptosis in bleomycin-induced pulmonary fibrosis
Source: Annual Congress 2008 - Management of idiopathic pulmonary fibrosis: what can we learn from the pathophysiology?
Year: 2008

Enhanced expression of Robo4 ameliorates LPS-induced acute lung injury in mice
Source: Annual Congress 2011 - Acute respiratory failure
Year: 2011

HSP47siRNA targeting to myofibroblasts attenuates bleomycin-induced pulmonary fibrosis
Source: Annual Congress 2012 - Interstitial lung disease: from bench to bedside
Year: 2012

Post-treatment with the heat shock protein 90 (hsp90) inhibitor, AUY-922, reduces lung hsp90 tyrosine (Y) phosphorylation and pulmonary inflammation in LPS-induced acute lung injury (ALI) in mice
Source: Annual Congress 2013 –The role of hormones and cytokines in lung injury
Year: 2013