Akt induced cytoplasmic mislocalization of p27kip1 protein and correlated with poor prognosis in lung adenocarcinoma

Y. Guo, Y. Xie, X. Wang, H. Yang, M. H. Lee (Guangzhou, China; Texas, United States Of America)

Source: Annual Congress 2008 - Biology and diagnosis of thoracic tumours
Session: Biology and diagnosis of thoracic tumours
Session type: E-Communication Session
Number: 4687
Disease area: Thoracic oncology

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Y. Guo, Y. Xie, X. Wang, H. Yang, M. H. Lee (Guangzhou, China; Texas, United States Of America). Akt induced cytoplasmic mislocalization of p27kip1 protein and correlated with poor prognosis in lung adenocarcinoma. Eur Respir J 2008; 32: Suppl. 52, 4687

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Prognostic significance and correlation between Akt phosphorylation and loss of PTEN protein expression in non-small cell lung cancer
Source: Eur Respir J 2005; 26: Suppl. 49, 458s
Year: 2005

Combined expression of p53, Bcl-2 and p21WAF-1 proteins in endobronchial biopsies may be associated with lung cancer prognosis
Source: Eur Respir J 2001; 18: Suppl. 33, 230s
Year: 2001

The prognostic value of altered pRb and p53 protein expression in non-small cell lung cancer
Source: Eur Respir J 2003; 22: Suppl. 45, 363s
Year: 2003

GSK-3 inhibition suppresses lung cancer cell survival, metastasis and proliferation through down-regulation the phosphorylation sites of CAP1
Source: International Congress 2017 – Lung cancer - basic science: the latest results from the bench
Year: 2017

Overexpression of inhibitor of DNA-binding proteins and angiogenic markers have higher impact on survival of non small cell lung cancer patients
Source: Annual Congress 2012 - New insights in the pathology of lung cancer
Year: 2012


The association of p53 and p21 expression with clinicopathological parameters and prognosis in non-small cell lung cancer
Source: Annual Congress 2010 - Prognostic factors for lung cancer
Year: 2010

Functional expressions of EGFP/LKB1 and its kinase domain induced apoptosis and enhanced chemosensitivity in lung cancer cell lines
Source: Eur Respir J 2004; 24: Suppl. 48, 5s
Year: 2004

Expression of survivin and p53 protein in pulmonary tumours
Source: Annual Congress 2011 - Progress in pathology of lung cancer
Year: 2011

Correlation between expression of p53, pRb, mdm2, p21WAF1/CIP1, PCNA, cyclin D1 and apoptotic index (AI) in non-small cell lung cancer (NSCLC) cells
Source: Annual Congress 2006 - Molecular pathology and genetics of lung cancer
Year: 2006


Overexpression of activated Akt does not correlate with radiologic chemoresponse
Source: Eur Respir J 2007; 30: Suppl. 51, 466s
Year: 2007

Radiation/cisplatin/vinorelbine therapy increase p53 protein phosphorylated at serine 392 in recurrent primary squamous cell lung cancer
Source: Eur Respir J 2001; 18: Suppl. 33, 17s
Year: 2001

BAX and p16INK4A are independent positive prognostic markers for advanced tumour stage of nonsmall cell lung cancer
Source: Eur Respir J 2002; 19: 134-140
Year: 2002



Fascin-1 overexpression predicts a poor prognosis in non-small cell lung cancer
Source: International Congress 2017 – Lung cancer - clinical research: scientific pearls from the bedside
Year: 2017

Expression of Fhit protein in non-small cell lung cancer (NSCLC) and its correlation with Ki-67, a proliferative marker
Source: Eur Respir J 2002; 20: Suppl. 38, 230s
Year: 2002

Nuclear expression of Y-Box binding protein (YB-1) as a negative prognostic marker in non-small cell lung cancer
Source: Annual Congress 2003 - Lung cancer biology
Year: 2003


Caspase recruitment domain containing protein 9 suppresses non-small cell lung cancer proliferation and invasion via inhibiting MAPK/p38 pathway
Source: Virtual Congress 2020 – Molecular alterations and immunology in lung cancer
Year: 2020

Translocation of beta-catenin into cytoplasm during TGFbeta-induced EMT is negatively regulated by phosphorylation of the PTEN C-terminus in lung cancers
Source: Annual Congress 2013 –Novel in vitro and animal models to study lung diseases
Year: 2013


Expression of p53, Bcl-2 and Bax in non-small cell lung cancer
Source: Eur Respir J 2007; 30: Suppl. 51, 512s
Year: 2007

p53 and mdm2 expression in nonsmall cell lung cancer (NSCLC): the lack of prognostic relevance
Source: Eur Respir J 2001; 18: Suppl. 33, 230s
Year: 2001

Involvement of proteasome inhibition and p53 accumulation in epithelial apoptosis of lung injury
Source: Eur Respir J 2005; 26: Suppl. 49, 101s
Year: 2005