Source: Annual Congress 2008 - Physiological response to exercise performance
Disease area: Airway diseases

Abstract

Few studies have evaluated the influence of the systemic inflammation in functional exercise capacity in patients with COPD. The aim of this study was to evaluate the influence of serum IL-6 on 6MWD performance in 77 patients with mild/very severe COPD (age: 63.7±9.2y; FEV₁:57.2±24.4%). Methods: Spirometry, fat free mass (FFM) by bioelectrical impedance, dyspnea perception by Modified Medical Research Council (MMRC) scale, serum levels of IL-6 and 6MWD were obtained at baseline. Predictors of 6MWD were determined by multiple regression analysis including age, gender, FEV₁%, FFM (kg), MMRC, IL-6 (pg/mL). We also examined models with first order interactions between IL-6 and age, gender, FEV₁, FFM and MMRC. An interaction between IL-6 and FEV₁ was found by backward regression analysis and its influence on walking distance was analyzed. Results: age (-2.46; 95%CI:-4.43,-0.5), IL-6 (-38.49; 95%CI:-57.84,-19.14), MMRC (-22.82;95%CI:-39.16,-6.49) and female gender (-54.23;95%CI:-103.81,-4.66) showed significant association with 6MWD (R²: 44.2%). When the interaction IL-6*FEV₁ was included in the model, age (-2.17; 95%CI:-4.11,-0.24), FEV₁ (1.52; 95%CI:0.41, 2.63), MRC (-25.04; 95%CI:-41.11,-8.97), female gender (-56.58;95%CI:-104.97,-8.19) and the interaction of IL-6*FEV₁(-0.95,95%CI:-1.85,-0.04) were associated with 6MWD and explained 47.9% of the 6MWD variation. These results suggest that the influence of IL-6 on 6MWD is stronger in patients with more severe disease. Conclusion: The systemic inflammation and the interaction between inflammation and airway obstruction influence the functional exercise capacity in COPD patients.

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S. Tanni, F. Sanchez, N. Pelegrino, M. Faganello, P. Lucheta, L. Inoue, I. Godoy (Botucatu/Sao Paulo, Brazil; Seatle, WA, United States Of America). Relationship between IL-6 and FEV₁ interaction and six minute walk distance (6MWD) performance in COPD patients. Eur Respir J 2008; 32: Suppl. 52, 3291

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