Source: Annual Congress 2008 - Factors related to outcome of community-acquired pneumonia
Disease area: Respiratory infections

Abstract

Background: Data about long-term mortality after community acquired pneumonia (CAP) is scarce. In most studies only short-term mortality is investigated. Aim of this CAPNETZ-substudy was to examine short- and long-term mortality after CAP and their influencing factors.
Methods: 1671 pts (61 ± 18 y., 45% w) with CAP were included. In all pts history, vital parameters, laboratory parameters and CRB-65 score were determined. Pts were followed up to 28 d and 180 d. The study population was divided into decades of age between 20 and 100 years.
Results: Overall mortality of CAP-pts was 4.5 % after 28 d and 10.6 % after 180 d. Thus, overall mortality was significantly higher after 28 d as well as after 180 d compared to an age matched cohort without CAP. Increased mortality at 180d could not be explained by excess short term mortality. Up to an age of 60 y., short- and long-term mortality after CAP is low and increases nearly exponentially with age. Factors with a significant association with mortality were age, comorbidities and CRB-65 score. Long-term mortality after 180 d was not influenced by physiologic alterations in the acute phase of CAP.
Conclusions: Long-term mortality 180 d after CAP is more than double compared to short-term mortality after 28 d. Compared to a normal age matched cohort a significant excess mortality after surviving the acute phase of CAP is remarkable. The reasons for this phenomenon are not sufficiently clarified. The main factor for short- and long-term mortality seems to be age, but there must be some others important factors that contribute to long-term mortality that have to be identified.

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S. Krueger, C. Schumann, R. Marre, N. Suttorp, T. Welte (Aachen, Berlin, Ulm, Hannover, Germany). Excess age dependent short- and long-term mortality in patients with community acquired pneumonia. Eur Respir J 2008; 32: Suppl. 52, 1557

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