The PDE4 inhibitor roflumilast N-oxide partly reversed TGFß1-induced changes in collagen I and E-cadherin expression in human airway epithelial cells

J. Milara, J. Cortijo, M. Mata, E. Donet, M. Mauricio, E. Morcillo (Valencia, Spain)

Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD
Session: Novel experimental approaches to understanding asthma and COPD
Session type: Thematic Poster Session
Number: 3648
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Milara, J. Cortijo, M. Mata, E. Donet, M. Mauricio, E. Morcillo (Valencia, Spain). The PDE4 inhibitor roflumilast N-oxide partly reversed TGFß1-induced changes in collagen I and E-cadherin expression in human airway epithelial cells. Eur Respir J 2008; 32: Suppl. 52, 3648

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The PDE4 inhibitor roflumilast N-oxide partly restored cigarette smoke (CS)-induced tight junction disassembly in human airway epithelial cells (Calu-3) – role of MAPK
Source: Annual Congress 2008 - Basic science in asthma and COPD II
Year: 2008

Effects of PDE4 inhibitors on eotaxin-3 (CCL26) expression in lung epithelial cells
Source: Annual Congress 2009 - Epithelial cell biology
Year: 2009


Effect of roflumilast, a PDE4 inhibitor, on ciliary beat frequency in human nasal epithelial cells
Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD
Year: 2008

Roflumilast N-oxide (RNO) alleviates from RSV-induced loss of ciliated cells and enhanced MUC5AC in differentiated human bronchial epithelial cells (D-HBE)
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

IL-13 induces glucocorticoid resistance in iNOS expression and activity in human airway epithelial cells (HAECs)
Source: International Congress 2017 – New insights into pathogenesis of lung disease 
Year: 2017


Effects of phosphodiesterase-4 inhibitors on surfactant protein-A expression in adult alveolar epithelial cells type II
Source: Annual Congress 2007 - Epithelial networks in the airways
Year: 2007


Protective effect of MAPK inhibitors and budesonide against apoptosis induced by TGF-β in primary cultures of human bronchial epithelial cells
Source: Eur Respir J 2003; 22: Suppl. 45, 394s
Year: 2003

Metformin regulates sirtuin expression in airway epithelial cells
Source: International Congress 2018 – New kids on the block: novel molecular pathways and therapeutic targets in chronic lung diseases
Year: 2018



Effects of the PDE4 inhibitor roflumilast n-oxide on the adherence of polymorphonuclear cells (PMNC) to bronchial epithelial cells (BEAS-2B) induced by non-typeable Haemophilus influenzae
Source: Annual Congress 2009 - Highlighting the epithelial cell in lung disease: from COPD to cancer to acute lung injury
Year: 2009


Cytokine-induced production of eotaxin-3 by human lung epithelial cells is inhibited by levocetirizine
Source: Eur Respir J 2005; 26: Suppl. 49, 98s
Year: 2005

Inhibition of human lung fibroblast functions by roflumilast N-oxide
Source: Eur Respir J 2006; 28: Suppl. 50, 662s
Year: 2006

Induction of apoptosis in murine alveolar epithelial cells by a proteasome inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 358s
Year: 2001

Secretory leucoprotease inhibitor (SLPI) inhibits IL-8 expression induced by double-stranded RNA in airway epithelial cells
Source: Annual Congress 2008 - Airway cell biology
Year: 2008


Kaempferol-induced HO-1 expression attenuated inflammation in human pulmonary alveolar epithelial cells
Source: International Congress 2017 – Therapeutic approaches in lung disease
Year: 2017


TGFβ-induced proteoglycan production and α-smooth muscle actin expression in cultured human lung fibroblasts is inhibited by combination of budesonide and formoterol
Source: Eur Respir J 2004; 24: Suppl. 48, 251s
Year: 2004

Roflumilast N-oxide, a PDE4 inhibitor, curbs bleomycin-induced lung fibroblast activation in vitro
Source: Annual Congress 2011 - Airway smooth muscle cells and fibroblasts: cell biology
Year: 2011


Anti-inflammatory effect of bosentan on endothelin-1- and TNF-α-induced GMCSF expression in human airways smooth muscle cells – role of MAPkinases ERK-1,-2
Source: Annual Congress 2007 - Inflammatory cell biology
Year: 2007


MMP regulation of apoptosis via Fas-pathway in human airway epithelial cells
Source: Eur Respir J 2003; 22: Suppl. 45, 77s
Year: 2003

Bosentan blocks TNFα-induced GM-CSF expression in human airway smooth muscle cells
Source: Annual Congress 2008 - Basic science in asthma and COPD
Year: 2008

The selective phosphodiesterase 4 inhibitor, cilomilast, inhibits interleukin-8-induced pulmonary neutrophil accumulation in the rabbit
Source: Eur Respir J 2001; 18: Suppl. 33, 35s
Year: 2001