Source: Annual Congress 2008 - Physiological response to exercise performance
Disease area: Airway diseases

Abstract

Impaired energy metabolism of skeletal muscles in Chronic Obstructive Pulmonary Disease patients is associated with muscle fibers distribution and activities of oxidative and glycolytic enzymes changes. We aimed to characterize modifications of energy metabolism at the Intra Cellular Energy Units system level, their relationships with oxidative stress and changes induced by endurance training. Two groups were studied: 9 COPD patients (62.3±11.4 years, FEV₁ 44.6±13.4% pred.) and 9 matched sedentary volunteers Controls (59.8±10.4 years). DXA scan, cardio-respiratory function, quadriceps force and fatigability were evaluated. Vastus lateralis biopsies were used to study mitochondrial respiration regulation by exogenous ADP with permeabilized fibres technique, oxidative stress and antioxidant defences. Participants underwent 12 weeks (45 min-day, 3 days/week) endurance home training using cyclo-ergometer. We obtained a significant decrease of mitochondrial respiration affinity for free ADP in COPD group (K_m^app 99.5±10 to 215±35 µM ADP) after rehabilitation and a strong respiratory control by creatine (K_m^app in the presence of creatine was 50.48±5.1µM for ADP and K_m^app for creatine in the presence of ATP was 1.09±0.04 µM). Mitochondrial Permeability Transition was induced by calcium quicker in COPD (calcium threshold is 44.2±3.9 µM) than sedentary subjects (77.3±7.3 µM Ca²⁺). The increase of Ca²⁺ threshold for mitochondria in situ after rehabilitation (59.5±8.9 µM Ca²⁺_, p=0.01) could be due to the decrease of its susceptibility to oxidative stress. Endurance training leads to enhanced muscle oxidative properties by regulating mitochondrial respiratory control and membrane permeability.
Funds: Agir@Dom.

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R. Guzun, V. Saks, B. Wuyam, E. Fontaine, P. Mezin, C. Garrel, E. Maclet, I. Hininger-Favier, J. L. Cracowski, A. M. Roussel, C. Auffrey, C. Pison (Grenoble, Paris, France). System muscle bioenergetic changes after home rehabilitation in patients with COPD. Eur Respir J 2008; 32: Suppl. 52, 3297

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