Source: Annual Congress 2008 - Physiological response to exercise performance
Disease area: Airway diseases

Abstract

Purpose: This study was conducted to investigate the effect of outpatients pulmonary rehabilitation (PR) that consisted of exercise training and nutritional support on systemic inflammation in COPD patients. Methods: Forty-two patients with stable COPD (42 male; mean (SD) age 76.0 (5.8)yrs, FVC 3.18 (0.72)L, FEV1 1.40 (0.60)L, %predicted FEV1 57.9 (24.5)%, FEV1/FVC 43.3 (14.1)%) were divided into a PR group and a control group (education only) . PR program consisted of respiratory muscle stretch gymnastics, breathing retraining, chest wall mobilization, chair exercise, and nutritional support using w-3 rich supplements (400 kcal/day).Respiratory muscle training (30%Pmax) was performed twice daily for 15 min. using a pressure threshold device. The patients visited outpatient clinic every two weeks. Lung functions, six-minute walking distance (6MWD), chronic respiratory questionnaire (CRQ), and inflammatory markers (hsCRP, TNFa, IL-6, IL-8) were evaluated before and three month after PR. Results: In the PR group, inflammatory markers decreased (hsCRP; 1.73 (1.61) vs 1.23 (1.26)mg/L(p<0.01), TNFa; 2.95 (2.52) vs 2.29 (1.77)pg/ml, IL-6; 2.26 (1.16) vs 2.04 (1.02), IL-8; 4.04 (2.29) vs 2.20 (0.48)pg/ml(p<0.01)). 6MWD increased significantly from 343 (153) to 397 (142)m (p<0.01). The total values of CRQ increased significantly from 97 (23) to 109 (22) (p<0.01). Whereas, these values in the control group did not change significantly. Conclusions: We conclude that pulmonary rehabilitation that consisted of exercise training and nutritional support might improve exercise capacity and HRQOL in COPD patients by improving systemic inflammation.

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K. Sugawara, H. Takahashi, C. Ksai, N. Kiyokawa, T. Watanabe, S. Fujii, M. Honma, M. Satake, T. Shioya (Akita, Japan). Pulmonary rehabilitation that consisted of exercise training and nutritional support improves systemic inflammation in patients with stable COPD. Eur Respir J 2008; 32: Suppl. 52, 3287

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