IFNγ induces steroid unresponsiveness in smokers alveolar macrophages

T. Southworth, H. Atcha, D. Singh (Manchester, United Kingdom)

Source: Annual Congress 2008 - Novel therapeutic approaches and immunological mechanisms in airway cell pathobiology
Session: Novel therapeutic approaches and immunological mechanisms in airway cell pathobiology
Session type: Thematic Poster Session
Number: 3713
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
T. Southworth, H. Atcha, D. Singh (Manchester, United Kingdom). IFNγ induces steroid unresponsiveness in smokers alveolar macrophages. Eur Respir J 2008; 32: Suppl. 52, 3713

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Glucocorticoid sensitivity of LPS stimulated COPD alveolar macrophages
Source: Annual Congress 2009 - COPD: basic science and clinical studies
Year: 2009

Induction of pro-inflammatory mediator release by cigarette smoke condensate: differential effects on alveolar epithelial cells and macrophages
Source: Eur Respir J 2003; 22: Suppl. 45, 81s
Year: 2003

Production of macrophage-derived chemokine by alveolar macrophages from cigarette smokers
Source: Eur Respir J 2003; 22: Suppl. 45, 454s
Year: 2003

No evidence of corticosteroid resistance in COPD alveolar macrophages
Source: Annual Congress 2009 - Translational research/biomarkers
Year: 2009


Glucocorticoids induce a shift in chemokine profile in LPS-stimulated human alveolar macrophages
Source: International Congress 2018 – Identification of therapeutic targets for asthma
Year: 2018

Azithromycin increases phagocytosis of apoptotic airway epithelial cells by alveolar macrophages in vitro
Source: Annual Congress 2005 - Cellular and molecular approaches to lung injury research
Year: 2005


Azithromycin increases phagocytosis of apoptotic bronchial epithelial cells by alveolar macrophages
Source: Eur Respir J 2006; 28: 486-495
Year: 2006



Increased SDF-1alpha production from alveolar macrophages in sarcoidosis in vitro
Source: Annual Congress 2008 - Sarcoidosis: pathophysiology and severity
Year: 2008

Resident alveolar macrophages mediate early alveolar epithelial death signaling and dysfunction
Source: Annual Congress 2012 - Novel mechanisms of acute lung injury
Year: 2012


A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages
Source: Eur Respir J, 55 (1) 1900646; 10.1183/13993003.00646-2019
Year: 2020



Preferential activation of alveolar macrophages versus epithelial cells during initiation of ventilator-induced lung injury in mice
Source: Annual Congress 2011 - Lung cell injury and repair
Year: 2011


Interferon-g or azathioprine plus corticosteroids do not alter the expression of apoptotic markers in alveolar macrophages of patients with IPF
Source: Annual Congress 2011 - Bronchoalveolar lavage and biomarkers in diffuse parenchymal lung disease
Year: 2011


Fluticasone increases in vitro efferocytosis by human alveolar macrophages
Source: Annual Congress 2010 - Asthma: clinical aspects and treatment
Year: 2010

Differential regulation of inflammatory pathways in alveolar macrophages from COPD patients and smoking controls
Source: Annual Congress 2007 - Novel mediators of cellular pathology
Year: 2007


IL-17A induces glucocorticoid insensitivity in airway epithelial cells
Source: Annual Congress 2011 - Epithelial cells: role in health and disease
Year: 2011


Cigarette smoke can increase the neutrophil recruitment in the airways of COPD patients by increasing PGE2 release in alveolar macrophages (AM)
Source: Eur Respir J 2003; 22: Suppl. 45, 85s
Year: 2003

Inhibition of cytokine release from alveolar macrophages in sarcoidosis by pentoxifylline: comparison with dexamethasone
Source: Eur Respir J 2001; 18: Suppl. 33, 195s
Year: 2001

Effect of cigarette smoke extract and Th17 cytokine on production of inflammatory cytokines and chemokines in human airway smooth muscle cells
Source: Virtual Congress 2021 – Airway pharmacology: translational and basic science
Year: 2021


Resveratrol impairs the release of steroid-resistant cytokines from bacterial endotoxin-exposed alveolar macrophages (AM) in COPD
Source: Annual Congress 2011 - Experimental modulation of airway inflammation
Year: 2011

Overexpression of CBP augments cigarette smoke-induced pro-inflammatory cytokine release in macrophages
Source: Eur Respir J 2005; 26: Suppl. 49, 105s
Year: 2005