Source: Annual Congress 2008 - Treatment and outcome of childhood asthma: new perspectives
Disease area: Airway diseases, Paediatric lung diseases

Abstract

Objective: There are only a few studies about nebulized magnesium sulfate in treatment of asthma attacks in children. The aim of this study was to determine the safety and efficacy of magnesium sulfate as a vehicle for nebulized salbutamol in asthma exacerbation.
Method: In a double blinded trial, forty asthmatic children (mean age = 3.55 years) randomly enrolled in two study groups. Each group of study treated with nebulized salbutamol. As a vehicle, 2.5 ml of normal saline or isotonic magnesium sulfate mixed with salbutamol for comparison of their potential effects. Respiratory distress scores were measured before and one hour after the second course of the treatment. Mean days of hospital stay and mean hours of need for oxygen were determined.
Results: The difference in improvement of mean scores of respiratory distress in magnesium sulfate and saline groups was insignificant (2.8±1, 95%CI: 2.8-1.9 vs. 2 ±1, 95% CI 2.8-1.8, p=0.97). The mean hours of oxygen therapy in magnesium sulfate and saline groups were 15.2 ± 12.5, 95% CI: 9.3-21.5 vs. 19 ± 14.3, 95% CI: 12.35-25.8 respectively (p=000). The mean days of hospitalization in magnesium sulfate and saline groups were 1.95 ± 0.9, 95%CI: -1.28 to 1.28 vs.2.1 ± 8.6, 95%CI: -1.35 to 1.35 respectively (p=0.73). There was no any side effect of magnesium sulfate in the study group.
Conclusion: Use of magnesium sulfate as a vehicle for nebulized salbutamol decreases the mean duration of oxygen therapy in patients with asthmatic attack. There were no differences in hospital stay and improvement of respiratory distress score in the study groups.

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Citations should be made in the following way:
J. Khashabi, S. Asadolahi, M. Karamiyar, S. Salari Lak (Urmia/West Azerbaijan, Islamic Republic Of Iran). Comparison of magnesium sulfate to normal saline as a vehicle for nebulized salbutamol in children with acute asthma; a clinical trial. Eur Respir J 2008; 32: Suppl. 52, 4597

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