Source: Annual Congress 2008 - Physiological response to exercise performance
Disease area: Airway diseases

Abstract

Further understanding of the metabolic adaptations to exercise training is important if maximal functional benefits from pulmonary rehabilitation (PR) are to be achieved in patients with COPD.
We previously demonstrated that plasma ammonia accumulation during exercise can reflect skeletal muscle adenine nucleotide metabolism in patients with COPD. The aim of this study was to determine the effects of exercise training as part of a PR programme on exercise-induced plasma ammonia accumulation.
Twenty-five patients with stable COPD [mean(SD) age 67(8)years, FEV₁ 47(18) %predicted] performed maximal cardiopulmonary exercise tests on a cycle ergometer and treadmill before and after completing a PR course. Blood ammonia and lactate concentrations were measured before and during exercise.
Peak cycle work and maximal treadmill walking distance increased significantly following PR. Exercise-induced plasma ammonia rise [mean(SEM) 24.0(2.8)umol/l in cycle and 19.6(2.4)umol/l in treadmill] was significantly attenuated post-PR, p<0.05. There was significant reduction in both blood lactate and plasma ammonia concentration (p<0.001) measured in the post-PR test at the same time/workload as peak pre-PR exercise (iso-time data).

PR significantly attenuated exercise-induced ammonia and lactate rise indicating that exercise training may improve skeletal muscle oxidative energy metabolism, allowing maintenance of ATP turnover during exercise.

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Citations should be made in the following way:
L. Calvert, S. Singh, M. Morgan, M. Steiner (Leicester, United Kingdom). Adaptation of the metabolic response to exercise following pulmonary rehabilitation in COPD. Eur Respir J 2008; 32: Suppl. 52, 3285

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