Association of polymorphisms of cytochrome P450 genes (CYP1A1 and CYP1A2 ) with chronic obstructive pulmonary disease in Tatars and Russians from Bashkortostan
G. Korytyna, Y. Dily, A. Lysan, Z. Shamil, V. Tatyana (Ufa, Russian Federation)
Source: Annual Congress 2007 - Mechanisms of exercise intolerance in cardiorespiratory disease
Session: Mechanisms of exercise intolerance in cardiorespiratory disease
Session type: Electronic Poster Discussion
Number: 296
Disease area: Airway diseases
Abstract To assess the role that polymorphisms of cytochrome P450 genes play in genetic predisposition to chronic obstructive pulmonary disease (COPD), the allele and genotype distributions of CYP1A1 (2455 A/G, 3801T/C) and CYP1A 2 (-2464T/delT, -163C/A) genes were studied in Tatar and Russian COPD patients (N=319) and in cases of ethnically matched healthy individuals (N=356), residents of Bashkortostan. It was shown that the CYP1A1 and CYP1A 2 genes haplotypes frequency distribution patterns not differed between Tatars and Russians ethnic groups (X2=0.973, df=3, P=1.00 and X2=1.546, df=3,P=0.92, respectively). The (-2467)delT allele and CYP1A2*1D haplotype of CYP1A2 gene was associated with higher risk of COPD in Tatar ethnic group (OR=1.83, 95%CI 1.24-2.71, X2=9.48, P=0.003 and X2=9.733, P=0.0027, Pcor =0.008; OR=3.908 95%CI 1.56-10.19, respectively).On the other hand the CYP1A2*1A haplotype had protective effect (X2=6.319, P=0.0127, Pcor =0.038; OR=0.6012 95%CI 0.402-0.898). But at the same time we did not find any differences in the genotypes and haplotypes frequency distributions of the CYP1A2 gene within the patients and healthy groups in Russian ethnic group. We also did not find any association of CYP1A1 gene with COPD in ethnic groups of Bashkortostan.
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G. Korytyna, Y. Dily, A. Lysan, Z. Shamil, V. Tatyana (Ufa, Russian Federation). Association of polymorphisms of cytochrome P450 genes (CYP1A1 and CYP1A2 ) with chronic obstructive pulmonary disease in Tatars and Russians from Bashkortostan. Eur Respir J 2007; 30: Suppl. 51, 296
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