Source: Annual Congress 2006 - Virus-induced respiratory tract infection
Disease area: Respiratory infections

Abstract

Aim of the investigation was to assess the role of cytomegalovirus (CMV) infection in the course of the chronic bronchitis (CB), chronic obstructive bronchitis (COB), bronchial asthma (BA) and tuberculosis (TB). Methods: 68 adult patients with CB, COB, BA and as control - 40 healthy people, 125 children with TB and as control - 45 children without TB were examined. CMV antibodies of classes Ig G and Ig M were determined by immunoferment analysis. Was shown that in children with TB percent of antibodies Ig G and Ig M was in 2,5 times higher than in control group(60,1 %, P<0,001). Ig M was revealed in 8 times more often in children with CMV (40,4 %) than in control group, P<0,001. Complications as dissemination in lungs, bacteriosecretion, chronic course of TB, disturbance of bronchial permeability in CMV infected children were established. A high prevalence of CMV infection (Ig G and Ig M) was revealed in adult patients with BA (100 %), with COB (78,0 %), with CB (55,2 %) but in healthy people – 45,6 %. Antibodies of Ig M were revealed more often in adult patients with BA (27,4 %) than in patients with CB (18,2 %, P < 0,05) and in healthy people - 6,8 %. Study of the course of COB in adult patients with CMV positive has shown significantly increase of CD8⁺ lymphocytes to (31,6 ± 0,9) than in patients with CMV negative (27,5 ± 1,7) that could negatively influence on bronchial obstruction. In patients with COB and active form CMV was revealed decrease the ratio of CD4/CD8 by 15,4 % to (1,4 + 0,06) in comparison with its ratio in patients without CMV, P < 0,01. Immune status in patients with CB infected CMV and uninfected CMV did not changed.

Rating:

Share or cite this content

Citations should be made in the following way:
E. E. Matusevych (Kiev, Ukraine). The frequency of cytomegalovirus infection detecting of patients with lung diseases. Eur Respir J 2006; 28: Suppl. 50, 963

Member's Comments

No comment yet.

Related content which might interest you: The role of cytomegalovirus infection in the course of the lung diseases in children Source: Eur Respir J 2005; 26: Suppl. 49, 643s Year: 2005 EBV and CMV as possible pathogens in patients presenting with interstitial lung disease Source: Eur Respir J 2006; 28: Suppl. 50, 154s Year: 2006 Cytomegalovirus infection in patients with lung tuberculosis Source: International Congress 2018 – Tuberculosis comorbidities Year: 2018 Incidence of viral infections in patients with lung transplantation Source: Annual Congress 2012 - Optimising outcomes after lung transplantation Year: 2012 Active cytomegalovirus infection in non-immunosuppressed children with chronic respiratory disease Source: Annual Congress 2012 - New insights into respiratory infections in children Year: 2012 Prevalence of CNS lesions in patients with pulmonary tuberculosis and HIV infection Source: International Congress 2019 – Tuberculosis: from diagnosis to complications Year: 2019 Increased LIR-1 expression precedes serum cytomegalovirus detection and diagnosis of CMV disease in lung transplant recipients Source: Eur Respir J 2002; 20: Suppl. 38, 347s Year: 2002 Epstein-Barr virus specific antibodies in patients with idiopathic pulmonary fibrosis and presence of EBV in respiratory tract: reactivation of infection? Source: Eur Respir J 2005; 26: Suppl. 49, 333s Year: 2005 Prevalence of virus infections in patients with asthma Source: Eur Respir J 2004; 24: Suppl. 48, 599s Year: 2004 Detection of IFN-γ responses for diagnosis of tuberculosis infection in chronic inflammatory disease patients Source: Annual Congress 2011 - Tuberculin skin tests, interferon-gamma release assays and beyond Year: 2011 Ultrastructure diagnostic of lung diseases for HIV - infection Source: Eur Respir J 2003; 22: Suppl. 45, 333s Year: 2003 COVID19 coinfection exacerbates lung inflammation in TB patients. Source: Virtual Congress 2021 – Tuberculosis, COVID-19 and other comorbidities Year: 2021 Effective prevention of human cytomegalovirus (HCMV) disease in lung transplant recipients (LTR) by pre-emptive therapy based on HCMV monitoring in blood and lung Source: International Congress 2019 – Lung transplantation: from bench to bedside Year: 2019 CT patterns of lung damage and prognosis markers for the course of a new coronavirus infection COVID-19 in persons with comorbidity Source: Virtual Congress 2021 – Biological and functional markers of COVID-19 Year: 2021 Human lung transplantation: cytomegaloviral and rhinoviral co-infection is a distinct risk for acute rejection Source: Annual Congress 2009 - Human and experimental lung transplantation: novel findings Year: 2009 The role of respiratory viruses in etiological structure of exacerbation of chronic and recurrent lung diseases in children Source: Eur Respir J 2007; 30: Suppl. 51, 391s Year: 2007 Age-related pattern of childhood lung infection and its complications Source: ISSN=1025-448x, ISBN=1-904097-22-7, page=189 Year: 2002 Pyogenic bacterial lower respiratory tract infection in human immunodeficiency virus-infected patients Source: Eur Respir J 2002; 20: 28S-39S Year: 2002 The prevalence and clinicopathologic feature of human papillomavirus infection in lung cancer patients Source: Annual Congress 2010 - Thoracic malignancies: interesting case studies and series Year: 2010 Cytomegalovirus damage of the lungs among patients with HIV-infection Source: Eur Respir J 2002; 20: Suppl. 38, 195s Year: 2002