Respiratory syncytial virus infection in childcare and hospitalized children with different respiratory disease severity
J. B. Salomão, L. G. Lourenção, C. Bittar, J. Ribeiro, F. P. Souza, P. Rahal, D. M. T. Zanetta (S.J. Rio Preto, Brazil)
Source: Annual Congress 2006 - Virus-induced respiratory tract infection
Session: Virus-induced respiratory tract infection
Session type: Oral Presentation
Number: 962
Disease area: Paediatric lung diseases, Respiratory infections
Abstract Respiratory syncytial virus (RSV) is a major cause of acute respiratory tract infection in children. To estimate the prevalence of RSV among children aged 0 to 6 years with mild and severe respiratory disease, a total of 293 respiratory secretions aspirated from nasopharynges of hospitalized (HC) and 710 from childcare (CC) children with acute respiratory illness were collected and stored in trizol at –70C. The diagnosis of RSV was made through reverse transcriptase-polymerase chain reaction (RT-PCR). The results are presented for children with <24 and ≥24 months of age. CC presented mild infection. Clinical presentations in HC were: 63.8% and 78.8% pneumonia; 22.1% and 27.5% bronchospasm; 23.5% and 0% bronquiolitis; 7.5% and 20% pleural effusion, in children with <24 and ≥24 months of age, respectively. Frequency of RSV are shown in Table 1.
RSV frequency among children with: <24 months* % of positive ≥24 month* % of positive Mild disease (all CC) 23/246 9.3 35/464 7.5 Severe disease (all HC) 64/213 30.0 21/80 26.3 Pneumonia 33/136 24.3 14/63 22.2 Bronchospasm 4/47 8.5 7/22 31.8 Bronquiolitis 32/50 64.0 0/0 Pleural effusion 5/16 31.3 3/16 18.7
* positive/Total of children with condition RSV was more prevalent in more severe diseases. The frequency of RSV in children with pneumonia was similar in both age groups, more frequent in older children with bronchospasm and in younger children with pleural effusion. All bronquiolitis occurred in younger children, who also had the highest frequency of RSV. Support by FAPESP .
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J. B. Salomão, L. G. Lourenção, C. Bittar, J. Ribeiro, F. P. Souza, P. Rahal, D. M. T. Zanetta (S.J. Rio Preto, Brazil). Respiratory syncytial virus infection in childcare and hospitalized children with different respiratory disease severity. Eur Respir J 2006; 28: Suppl. 50, 962
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