Source: Annual Congress 2006 - Clinical aspects of tuberculosis
Disease area: Airway diseases

Abstract

We performed a retrospective study, between January 2001 and December 2005. We evaluated lung functions (the forced expiratory volume in 1s - FEV1, the oxygen saturation) the postbronchodilator responses and the necessity of supplemental oxygen in 224 patients (152 males and 72 females, mean age 57 years) with concomitant pulmonary tuberculosis sequelae (TBS) after at least 2 years of treatment completion and chronic airflow obstruction, and we compared these results with those of 787 patients with COPD (504 males and 283 females, mean age 62.8 years). In the TBS group the FEV1 was ≥ 80% of the predicted value in 14% patients and < 30% in 12.5% patients. We used the GOLD staging for COPD: mild – 5.7% patients, moderate – 23.5%, severe – 51.8 % and very severe – 19%. COPD patients were more responsive to bronchodilator than those with TBS, 19.6% cases respectively 11% had a change of FEV1 of more than 12%. In a higher percentage in TBS patients than in COPD patients are seen: the chronic respiratory failure - 34% cases respectively 23.5%, cor pulmonale - 15.6% respectively 9.2% and long-term oxygen therapy - 5.3% respectively 2.3% cases. The TBS patients were younger than COPD patients. Because the pathophysiology of chronic airflow obstruction due to tuberculosis lung disorder differs from that of COPD, the TBS patients have more limited functional resources and they were less responsive to treatment. Although they can have a long insidious period of evolution, the precipitating factors lead faster to the respiratory failure, cor pulmonale and reduce the quality of life of these patients.

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Citations should be made in the following way:
O. I. Nicolaescu (Bucharest, Romania). Lung comparative function in COPD patients and in patients with chronic airflow obstruction due to tuberculosis lung disorder. Eur Respir J 2006; 28: Suppl. 50, 823

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