Source: Annual Congress 2006 - Clinical aspects of tuberculosis
Disease area: Paediatric lung diseases, Respiratory infections

Abstract

In Ukraine 2 epidemics – TB and AIDS are registered. Clinical observations testify to the growth of the number of children with TB/HIV. Official statistics do not reflect a real situation on TB/HIV in children.
The aim was to study clinical peculiarities of TB/HIV in children.
Results: a 16 cases of TB combined with HIV infection were analyzed, 3 children were under 1 year of age, 4 - under 3 years, 8 under 7 years, 1 - 17 years old.
16 children were born from HIV-infected mothers. A 17 year-old boy used injected narcotics. Contact with TB patient was revealed in 50%, 4 sources of infection had TB/HIV. 13 children were from socially vulnerable families, 3 children were abandoned by mothers, 3 school age children experienced heavy social stigmatization. Only 2 children received ART-therapy. In any case no prophylaxis of a vertical HIV transmission was done. In 4 children a primary TB complex was revealed, in 4 children – TB of intrathoracic lymphatic nodes, in 8 - disseminated pulmonary TB. In 4 children apart from pulmonary lesion, a generalized process with the lesion of intestine, mesenterial lymphatic nodes, peritoneum and other organs was revealed. 4 children were BCG vaccinated. 7 children died of TB/HIV. In 2 children postmortal TB diagnosis was made.Conclusion: clinical analysis allowed to reveal the following variants of TB in HIV-infected children: 1.General uncomplicated TB course with a good dynamics received due to antituberculous therapy. 2. Prevalent and progressive forms with lungs lesion and that of other organs (in late diagnostics, immunosupressions by CD4). 3. Even in effective treatment of TB in HIV-infected children the marked residual changes in the lungs remain.

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Citations should be made in the following way:
O. I. Belogortseva (Kiev, Ukraine). Tuberculosis and HIV-infection in children of Ukraine. Our first experience. Eur Respir J 2006; 28: Suppl. 50, 815

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