Source: Annual Congress 2006 - Clinical aspects of tuberculosis
Disease area: Respiratory infections

Abstract

Study objectives : To define the factors associated with mortality following the in-hospital diagnosis of tuberculosis in a region with low levels of coinfection with HIV.
Methods : From January 2003 to December 2004, all subjects who were > 15 years of age and had received a diagnosis of pulmonary tuberculosis were registered. The clinical and laboratory aspects of the patients who died (n=27) were compared with those of an age and gender matched control population(n=54). Logistic regression analyses were performed including age, gender, hospital admission source, initial site of admission, dyspnea, general weakness and initial laboratory data.
Results : The mean age of patients was 60±16 years and male patients outnumbered female patients. Univariate analysis identified hemoglobin, blood urea nitrogen, albumin, cholesterol, AST, C-reactive protein and risk factors for tuberculosis that were significantly associated with mortality. Among the characteristics of disease presentation and treatment, emergency department admission, intensive care unit, general weakness, dyspnea at the time of hospital admission and military disease were associated with mortality. In a multivariable analysis, initial management of intensive care unit and lower albumin were independently associated with mortality.
Conclusion : The factors that appear to contribute to in-hospital mortality are markers of disease chronicity and severity of the tuberculosis. The identification of potentially reversible factors such as malnutrition and respiratory failure suggests specific intervention that may lead to improvement in patient outcomes.

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Y. B. Park, S. M. Park, K. S. Eom, E. K. Mo, M. G. Lee, K. S. Jung (Seoul, Republic Of Korea). Predictors of in-hospital mortality following in-hospital diagnosis of tuberculosis. Eur Respir J 2006; 28: Suppl. 50, 814

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