Are there any long-term cardio-pulmonary limitations of hospitalized Covid-19 patients?

R. Badr-Eslam (Vienna, Austria), R. Mousavi (Vienna, Austria), C. Binder-Rodriguez (Vienna, Austria), A. Iscel (Vienna, Austria), J. Niebauer (Vienna, Austria), C. Kronberger (Vienna, Austria), C. Wenisch (Vienna, Austria), D. Bonderman (Vienna, Austria)

Source: Respiratory Failure and Mechanical Ventilation Conference 2022 - Opening session: Essentials of respiratory physiology - Assessment of respiratory muscle function - Pulmonary infections in mechanically ventilated patients - Telemonitoring of patients with chronic respiratory failure - Diagnostics and interventions - Acute respiratory failure: COVID-19 - Interstitial lung disease and pulmonary hypertension - Early rehabilitation - Acute respiratory failure: Invasive mechanical ventilation - HFNO and NIV for acute hypoxemic failure - Longterm NIV miscellaneous - Controversies in acute respiratory failure - The role of respiratory muscle dysfunction in weaning failure - Transitions in chronic NIV - New insights in weaning from invasive ventilation - Noninvasive ventilation (NIV) in the clinical practice: How do I do it? - Difficult weaning from mechanical ventilation - Chronic ventilatory support in different diseases: Is one way fitting all? - Strategies to optimise early mobilisation and rehabilitation in intensive care - Noninvasive ventilation (NIV) in the clinical practice: How do I do it? - Acute respiratory failure: Hypercapnic and diagnosis - Weaning from mechanical ventilation

Session: Weaning from mechanical ventilation
Session type: Oral poster discussion
Number: 106

Abstract

Background:

The Covid-19 pandemic has affected our lives for over a year and almost 500.000 people in Austria have been infected. The aim of this study was to perform a follow-up cardiopulmonary exercise test (CPET) on those patients to find out if there are long-term cardio-pulmonary limitations (CPL) of COVID-19 and to check if there is any difference in outcome and CPL between patients who received oxygen therapy vs. without oxygen therapy.

Methods:

40 patients were included into this study. All patients were hospitalized during their infection with Covid-19 and underwent CPET 6 ± 2 month after discharge. 20 patients (50%) received oxygen therapy or ventilation during their hospitalization. CPL was defined as VO2% of Predicted = 84%, VE/CO2 Slope =34 and RER at peak of exercise = 1.1.

Results:

When comparing the two groups, we found higher percentage of CPL in patients who received oxygen therapy during their hospitalization. The median VO2 % of predicted was 88.0% without oxygen therapy vs. 84.5% with oxygen therapy (p=0.289), the median HR percentage of predicted was 92.5% without oxygen therapy vs. 94.5% with oxygen therapy (p=0.478), the median physical performance in watt in patients without oxygen therapy was 130.0 vs. 135.0 with oxygen therapy (p=0.820).

Conclusion:

Our study did not show any significant difference in long-term CPL the 2 groups. Therefore, other causes of the exercise intolerance and dyspnoea have to be discussed multidisciplinary. Overall, 7.5% of our patients showed CPL although those patients didn’t have any clinical symptoms. Therefore, CPET is a good method to discover asymptomatic patients with CPL.

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Citations should be made in the following way:
R. Badr-Eslam (Vienna, Austria), R. Mousavi (Vienna, Austria), C. Binder-Rodriguez (Vienna, Austria), A. Iscel (Vienna, Austria), J. Niebauer (Vienna, Austria), C. Kronberger (Vienna, Austria), C. Wenisch (Vienna, Austria), D. Bonderman (Vienna, Austria). Are there any long-term cardio-pulmonary limitations of hospitalized Covid-19 patients?. Respiratory Failure and Mechanical Ventilation Conference 2022 - Opening session: Essentials of respiratory physiology - Assessment of respiratory muscle function - Pulmonary infections in mechanically ventilated patients - Telemonitoring of patients with chronic respiratory failure - Diagnostics and interventions - Acute respiratory failure: COVID-19 - Interstitial lung disease and pulmonary hypertension - Early rehabilitation - Acute respiratory failure: Invasive mechanical ventilation - HFNO and NIV for acute hypoxemic failure - Longterm NIV miscellaneous - Controversies in acute respiratory failure - The role of respiratory muscle dysfunction in weaning failure - Transitions in chronic NIV - New insights in weaning from invasive ventilation - Noninvasive ventilation (NIV) in the clinical practice: How do I do it? - Difficult weaning from mechanical ventilation - Chronic ventilatory support in different diseases: Is one way fitting all? - Strategies to optimise early mobilisation and rehabilitation in intensive care - Noninvasive ventilation (NIV) in the clinical practice: How do I do it? - Acute respiratory failure: Hypercapnic and diagnosis - Weaning from mechanical ventilation

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