Source: Annual Congress 2007 - COPD and comorbidity
Disease area: Airway diseases

Abstract

Ischemic heart disease (IHD) is most wide-spread disease in adult people. Little is known about its combination with COPD. We study frequency and peculiarity of IHD in patients with COPD.
Materials and methods. 233 patients with COPD have been studied (aged 55,2±0,61): 74 patients with mild and moderate COPD and 159 patients with severe COPD. Diagnosis of COPD was made according to the ERS standards. Diagnosis IHD was made if patients have myocardial infarction (MI) and angina pectoris.
Results. 28.8% patients have IHD: MI in 33 patients, angina pectoris in 30 patients. NonQ-infarct was in 17 patients, Q-infarct – in 16 patients. 17 patients (51.5%) with MI have non-pain infarction, 54.2% have anterior infarction, 45.8% - ihferior MI. All patients divided in 2 groups: with and without IHD. Patients with IHD was higher (p<0.001), have more severe bronchial obstruction (p<0.01), duration and intensity of smoking (p<0.001 and p<0.01) than patients without IHD. But patients with IHD did not differ from patients without IHD on body mass index, level of cholesterol, frequency of arterial hypertension. Patients with severe COPD have MI in 2.1 times more than patients with mild and moderate COPD (17.1% and 8%). Patients with IHD has 1.6 times more CRP> 3mg/l than patients without IHD (42.3% and 26%). There are correlations between CRP and FEV1 in patients with IHD (r=-0.44, p<0.05), mainly in patients with MI (r=-0.81, p<0.01).
Conclusions. The data presented in this study indicate that COPD, especially with severe bronchial obstruction, associated with ischemic heart disease independent other risk factor of IHD. Age, FEV1, duration and intensity of smoking, systemic inflammation (CRP) are associated with coronary disease in patents with COPD.

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Citations should be made in the following way:
N. Karoli, A. Rebrov (Saratov, Russian Federation). Ischemic heart disease in patients with COPD. Eur Respir J 2007; 30: Suppl. 51, 4150

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