Molecular genetic markers associated with course of severe COVID-19 pneumonia. Different pathways study.

N. Gorovenko (Kyiv, Ukraine), M. Ostrovskyy (Ivano-Frankivsk, Ukraine), Z. Rossokha (Kyiv, Ukraine), L. Fishchuk (Kyiv, Ukraine), N. Korzh (Ivano-Frankivsk, Ukraine), V. Vershyhora (Kyiv, Ukraine), O. Dubitskaya (Kyiv, Ukraine), N. Medvedieva (Kyiv, Ukraine), O. Popova (Kyiv, Ukraine)

Source: International Congress 2022 – New mechanistic insights into acute and chronic interstitial lung disorders
Session: New mechanistic insights into acute and chronic interstitial lung disorders
Session type: Thematic Poster
Number: 2803

Congress or journal article abstractE-poster

Abstract

Introduction. It is known that the development of COVID-19 in the human body consists of complex system of biological mechanisms underlying the complex interplay between infectious agents and the human host. This raised the question about hosts’ genetic variants as predictors of clinical phenotype. The aim of our study was to analyze the effect of the NOS3 gene (VNTR intron 4 a/b), NR3C1 gene (C647G, rs41423247) and the SFTPB gene (C1580T, rs11130866) variants on the course of severe COVID-19 pneumonia in patients.

Materials and Methods. The study group included 20 patients (13 men and 7 women) with diagnosis “viral COVID-19 pneumonia” treated at the intensive care unit. Investigation of the NOS3, NR3C1 and SFTPB genes variants was carried out by a molecular method using PCR-RFLP and allele-specific PCR, respectively.

Results. The correlation analysis showed a significant association of the NOS3 gene variants and level of SpO2 (rS=-0.488, p=0.029; SpO2=93.1±2.4% for b/b and SpO2=82.0±1.1% for a/a genotypes). Also a significant  positive correlation was between NR3C1 gene variants and duration of nasal intermittent positive pressure ventilation (nIPP) therapy (rS=0.454, p=0.044; for 647CC – 1.5±1.0 days and for 674GG – 3.9±2.5 days), presence of fever (need for antipyretics) (rS=0.525, p=0.017; 647C vs 647G alleles – ?2=5.8, p=0.016). No significant correlations were found for the variants of SFTPB gene.

The obtained results support a hypothesis about the combined influence of different pathways genes variants (NOS3 and NR3C1) on severity of COVID-19. However, in order to draw definite conclusions, further multifaceted research in this area are need.



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N. Gorovenko (Kyiv, Ukraine), M. Ostrovskyy (Ivano-Frankivsk, Ukraine), Z. Rossokha (Kyiv, Ukraine), L. Fishchuk (Kyiv, Ukraine), N. Korzh (Ivano-Frankivsk, Ukraine), V. Vershyhora (Kyiv, Ukraine), O. Dubitskaya (Kyiv, Ukraine), N. Medvedieva (Kyiv, Ukraine), O. Popova (Kyiv, Ukraine). Molecular genetic markers associated with course of severe COVID-19 pneumonia. Different pathways study.. 2803

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