REDES study: Mepolizumab is effective in patients with severe eosinophilic asthma and comorbid NP
E. Arismendi Nunez (Barcelona, Spain), C. Cisneros (Madrid, Spain), M. Blanco-Aparicio (A Coruña, Spain), D. Bañas Conejero (Madrid, Spain), A. Moure (Madrid, Spain), M. Sánchez-Herrero (Madrid, Spain)
Source: International Congress 2022 – Studies targeting IL-5 pathways in asthma
Session: Studies targeting IL-5 pathways in asthma
Session type: Thematic Poster
Number: 2125
AbstractIntroduction:
REDES was a multicenter, retrospective, observational, real world study on the effectiveness and safety of 100 mg SC mepolizumab in Severe Eosinophilic Asthma (SEA) patients in Spain (n=318).
Methods:
This post hoc analysis described the demographic features and mepolizumab effectiveness according to the presence or absence of comorbid NP, a condition commonly present in an eosinophilic severe asthmatic phenotype.
Results:
147 (46.2%) patients had a diagnosis of comorbid NP, with baseline eosinophils levels of 799 eos/µL (SEA without NP: 634 eos/µL). After 12 months of mepolizumab therapy, SEA+NP patients experienced an 83.4% reduction in annual exacerbation rates (SEA without NP: 73.0%, p=0.0017) and 53.7% of patients requiring maintenance therapy with oral corticosteroids were able to completely discontinue (SEA without NP: 42.9%). At the end of the year, all SEA patients also had improved asthma control, 76.0% with ACT>20 in SEA+NP vs 69.8% in SEA without NP, and improved their lung function: 0.23L in FEV1 (pre-BD) in SEA+NP vs 0.18L in SEA without NP (intergroup p=ns).
Conclusion:
Whilst mepolizumab is an effective treatment for SEA patients with and without a diagnosis of comorbid NP, those with SEA+NP represent a clinical phenotype who respond particularly well to mepolizumab therapy.
Funding: GSK (ID 213172)
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E. Arismendi Nunez (Barcelona, Spain), C. Cisneros (Madrid, Spain), M. Blanco-Aparicio (A Coruña, Spain), D. Bañas Conejero (Madrid, Spain), A. Moure (Madrid, Spain), M. Sánchez-Herrero (Madrid, Spain). REDES study: Mepolizumab is effective in patients with severe eosinophilic asthma and comorbid NP. 2125
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