Modification of gene expression and increase in alpha-1-antitrypsin (α1AT) secretion after homologous recombination in α1AT deficient monocytes

G. McNab, R. Stockley (Birmingham, United Kingdom)

Source: Annual Congress 2007 - Inflammatory cell biology
Session: Inflammatory cell biology
Session type: Electronic Poster Discussion
Number: 4075

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
G. McNab, R. Stockley (Birmingham, United Kingdom). Modification of gene expression and increase in alpha-1-antitrypsin (α1AT) secretion after homologous recombination in α1AT deficient monocytes. Eur Respir J 2007; 30: Suppl. 51, 4075

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Decreased expression of DNA synthesis repair recombination proteins in lungs of senescence accelerated mouse (SAM)
Source: Eur Respir J 2003; 22: Suppl. 45, 73s
Year: 2003

Differential expression of the S1P transporter, Spinster homologue 2 (Spns2), in airway epithelial cells and macrophages may drive defective macrophage function in COPD
Source: International Congress 2017 – Cigarette smoke and particulate matter: basic science and clinical aspects
Year: 2017

Alpha1-antitrypsin regulates CD14 expression and soluble CD 14 levels in human monocytes in vitro
Source: Annual Congress 2007 - Molecular pathogenesis: focus on COPD and asthma
Year: 2007


Study of gene expression control elements of the human SP-A genes: Role of the 5‘UTR exon B
Source: Annual Congress 2010 - Recent developments of molecular pathology and functional genomics in chronic and acute airway diseases
Year: 2010


Mannan-binding lectin (MBL) structural gene mutations, promoter polymorphism and circulating protein levels in pulmonary tuberculosis
Source: Annual Congress 2003 - Genetics and immunobiology of tuberculosis
Year: 2003


Regulation of γ-GCS gene expression by TGF-β in type II epithelial cells: role for Fra-1/AP-1/ARE
Source: Eur Respir J 2002; 20: Suppl. 38, 96s
Year: 2002

Early growth response gene expression in neutrophils
Source: Eur Respir J 2004; 24: Suppl. 48, 551s
Year: 2004

Hypoxia Inducible Factor-1α binding to HDAC2 and MIF promoter regions is associated with changes in gene expression levels in chronic ozone exposed mice
Source: Annual Congress 2011 - Immunology and cell biology of asthma and COPD
Year: 2011


Increased expression of α1-hydroxylase (CYP27B1) in IL-13-exposed primary bronchial epithelial cells (PBEC): Consequences for activation of vitamin D and expression of the antimicrobial peptide hCAP-18/LL-37
Source: Annual Congress 2011 - Epithelial cell biology
Year: 2011


Mutation and functional analysis of the IL-18 promoter in sarcoidosis: a potential role for single nucleotide polymorphisms in cytokine expression regulation
Source: Eur Respir J 2003; 22: Suppl. 45, 180s
Year: 2003

Coordinate regulation of IL-4 and IL-13 expression in human T cells: 3C analysis for DNA looping
Source: Annual Congress 2011 - Molecular: pathology of infectious and inflammatory lung disease
Year: 2011

PDK1/RSK1-dependent C/EBPß activation is involved in thrombin-induced expression of orosomucoid 1-like 3 (ORMDL3) and IL-8/CXCL8 in human lung epithelial cells
Source: International Congress 2017 – Asthma: mechanisms and treatment
Year: 2017


Immunomodulation capacity of alpha-1 antitrypsin in regulation of CD14 molecules expression and secretion in human monocytes in vitro
Source: Annual Congress 2011 - New mechanisms in airway disease
Year: 2011


Influence of heparin binding protein (HBP) on pro-inflammatory signal transduction and ICAM-1 expression in A549 cells
Source: Eur Respir J 2004; 24: Suppl. 48, 100s
Year: 2004

Effects of adenoviral gene transfer of mutated IκBα, a novel inhibitor of NF-κB, on human monocyte-derived dendritic cells
Source: Eur Respir J 2006; 28: Suppl. 50, 759s
Year: 2006

Novel genetic variants in alpha-1 antitripsin deficiency cases carrying S alleles and discordant genotype and serum levels
Source: International Congress 2015 – Promising novel findings in translational pulmonary research
Year: 2015

Glucocorticosteroid receptor (GCR) gene isoforms expression in bronchial asthma (BA) patients
Source: Annual Congress 2011 - Asthma: a heterogeneous disease
Year: 2011


Increased apolipoprotein E (ApoE) gene expression in an alveolar macrophage subpopulation of NO2-exposed rats
Source: Eur Respir J 2004; 24: Suppl. 48, 102s
Year: 2004

Alteration of ROS metabolism and cell type-specific differentiation markers in the lungs of Pex11β (-/-) mice, a mouse model deficient in peroxisome proliferation
Source: Annual Congress 2008 - Cell biology of asthma and COPD
Year: 2008



Increased proliferation of type 2 alveolar epithelial cells in a pneumonectomy model mice with a deletion of p16ink4a gene.
Source: International Congress 2018 – Regenerative and anti-fibrotic approaches
Year: 2018