Genetic polymorphisms, vitamin D binding protein and vitamin D deficiency in COVID-19

Marijn M. Speeckaert, Reinhart Speeckaert, Joris R. Delanghe

Source: Eur Respir J, 57 (5) 2004638; 10.1183/13993003.04638-2020

Journal Issue: May

Abstract

With interest, we read the paper of Faniyi et al. [1], which investigated the relationship between vitamin D status and seroconversion for coronavirus disease 2019 (COVID-19) in UK healthcare workers. More specifically, vitamin D deficiency was an independent risk factor for the development of COVID-19 seroconversion, with the biggest differences seen in the Black, Asian and minority ethnic (BAME) male group. Although several comorbidities were taken into account, we would like to highlight the importance of vitamin D binding protein (DBP) and its polymorphism in the interpretation of low 25-hydroxyvitamin D (25(OH)D) levels in the BAME population with COVID-19.

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Marijn M. Speeckaert, Reinhart Speeckaert, Joris R. Delanghe. Genetic polymorphisms, vitamin D binding protein and vitamin D deficiency in COVID-19. Eur Respir J, 57 (5) 2004638; 10.1183/13993003.04638-2020

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