Risk of acute arterial and venous thromboembolic events in eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome) Alessandra Bettiol, Renato Alberto Sinico, Franco Schiavon, Sara Monti, Enrica Paola Bozzolo, Franco Franceschini, Marcello Govoni, Claudio Lunardi, Giuseppe Guida, Giuseppe Lopalco, Giuseppe Paolazzi, Angelo Vacca, Gina Gregorini, Pietro Leccese, Matteo Piga, Fabrizio Conti, Paolo Fraticelli, Luca Quartuccio, Federico Alberici, Carlo Salvarani, Silvano Bettio, Simone Negrini, Carlo Selmi, Savino Sciascia, Gabriella Moroni, Loredana Colla, Carlo Manno, Maria Letizia Urban, Alfredo Vannacci, Maria Rosa Pozzi, Paolo Fabbrini, Stefano Polti, Mara Felicetti, Maria Rita Marchi, Roberto Padoan, Paolo Delvino, Roberto Caporali, Carlomaurizio Montecucco, Lorenzo Dagna, Adriana Cariddi, Paola Toniati, Silvia Tamanini, Federica Furini, Alessandra Bortoluzzi, Elisa Tinazzi, Lorenzo Delfino, Iuliana Badiu, Giovanni Rolla, Vincenzo Venerito, Florenzo Iannone, Alvise Berti, Roberto Bortolotti, Vito Racanelli, Guido Jeannin, Angela Padula, Alberto Cauli, Roberta Priori, Armando Gabrielli, Milena Bond, Martina Tedesco, Giulia Pazzola, Paola Tomietto, Marco Pellecchio, Chiara Marvisi, Federica Maritati, Alessandra Palmisano, Christian Dejaco, Johann Willeit, Stefan Kiechl, Iacopo Olivotto, Peter Willeit, Domenico Prisco, Augusto Vaglio, Giacomo Emmi
Source: Eur Respir J, 57 (5) 2004158; 10.1183/13993003.04158-2020 Abstract
Eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg–Strauss syndrome) is a rare anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) characterised by respiratory manifestations and systemic organ involvement [1]. Particularly, cardiac manifestations occur in 40–60% of patients, representing the leading cause of mortality [2]. Recent reports suggest that venous thromboembolic events might also represent a consistent burden of disease [3, 4], as already known for the other AAVs [5–7], possibly due to eosinophil-mediated vascular inflammation [5]. Nevertheless, the occurrence of arterial and venous thrombotic events (AVTEs) has never been systematically explored in EGPA.
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Alessandra Bettiol, Renato Alberto Sinico, Franco Schiavon, Sara Monti, Enrica Paola Bozzolo, Franco Franceschini, Marcello Govoni, Claudio Lunardi, Giuseppe Guida, Giuseppe Lopalco, Giuseppe Paolazzi, Angelo Vacca, Gina Gregorini, Pietro Leccese, Matteo Piga, Fabrizio Conti, Paolo Fraticelli, Luca Quartuccio, Federico Alberici, Carlo Salvarani, Silvano Bettio, Simone Negrini, Carlo Selmi, Savino Sciascia, Gabriella Moroni, Loredana Colla, Carlo Manno, Maria Letizia Urban, Alfredo Vannacci, Maria Rosa Pozzi, Paolo Fabbrini, Stefano Polti, Mara Felicetti, Maria Rita Marchi, Roberto Padoan, Paolo Delvino, Roberto Caporali, Carlomaurizio Montecucco, Lorenzo Dagna, Adriana Cariddi, Paola Toniati, Silvia Tamanini, Federica Furini, Alessandra Bortoluzzi, Elisa Tinazzi, Lorenzo Delfino, Iuliana Badiu, Giovanni Rolla, Vincenzo Venerito, Florenzo Iannone, Alvise Berti, Roberto Bortolotti, Vito Racanelli, Guido Jeannin, Angela Padula, Alberto Cauli, Roberta Priori, Armando Gabrielli, Milena Bond, Martina Tedesco, Giulia Pazzola, Paola Tomietto, Marco Pellecchio, Chiara Marvisi, Federica Maritati, Alessandra Palmisano, Christian Dejaco, Johann Willeit, Stefan Kiechl, Iacopo Olivotto, Peter Willeit, Domenico Prisco, Augusto Vaglio, Giacomo Emmi. Risk of acute arterial and venous thromboembolic events in eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome). Eur Respir J, 57 (5) 2004158; 10.1183/13993003.04158-2020
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