RCT Abstract - Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomized, double-blind, placebo-controlled, phase 3 trial

J. Naccache (Paris, France), S. Jouneau (Rennes, France), M. Didier (Bobigny, France), R. Borie (Paris, France), M. Cachanado (Paris, France), A. Bourdin (Montpellier, France), M. Reynaud-Gaubert (Marseille, France), P. Bonniaud (Dijon, France), D. Israel-Biet (Paris, France), G. Prevot (Toulouse, France), S. Hirschi (Strasbourg, France), F. Lebargy (Reims, France), S. Marchand-Adam (Tours, France), N. Bautin (Lille, France), J. Traclet (Lyon, France), E. Gomez (Nancy, France), S. Leroy (Nice, France), F. Gagnadoux (Angers, France), F. Rivière (Clamart, France), E. Bergot (Caen, France), A. Gondouin (Besançon, France), E. Blanchard (Bordeaux, France), A. Parrot (Paris, France), F. Blanc (Nantes, France), A. Chabrol (Suresnes, France), S. Dominique (Rouen, France), A. Gibelin (Paris, France), A. Tazi (Paris, France), L. Berard (Paris, France), P. Brillet (Bobigny, France), M. Debray (Paris, France), A. Rousseau (Paris, France), M. Kerjouan (Rennes, France), O. Freynet (Bobgny, France), M. Dombret (Paris, France), A. Gamez (Montpellier, France), A. Nieves (Marseille, France), G. Beltramo (Dijon, France), J. Pastré (Paris, France), A. Le Borgne-Krams (Toulouse, France), T. Dégot (Strasbourg, France), C. Launois (Reims, France), L. Plantier (Tours, France), L. Wémeau-Stervinou (Lille, France), J. Cadranel (Paris, France), C. Chenivesse (Lille, France), D. Valeyre (Bobigny, France), B. Crestani (Paris, France), V. Cottin (Lyon, France), T. Simon (Paris, France), H. Nunes (Bobigny, France), On Behalf Of The Orphalung Network

Source: Virtual Congress 2021 – ALERT: Asthma in adult, in children and ILDs
Session: ALERT: Asthma in adult, in children and ILDs
Session type: Clinical trials session
Number: 2903

Congress or journal article abstractWebcastSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Naccache (Paris, France), S. Jouneau (Rennes, France), M. Didier (Bobigny, France), R. Borie (Paris, France), M. Cachanado (Paris, France), A. Bourdin (Montpellier, France), M. Reynaud-Gaubert (Marseille, France), P. Bonniaud (Dijon, France), D. Israel-Biet (Paris, France), G. Prevot (Toulouse, France), S. Hirschi (Strasbourg, France), F. Lebargy (Reims, France), S. Marchand-Adam (Tours, France), N. Bautin (Lille, France), J. Traclet (Lyon, France), E. Gomez (Nancy, France), S. Leroy (Nice, France), F. Gagnadoux (Angers, France), F. Rivière (Clamart, France), E. Bergot (Caen, France), A. Gondouin (Besançon, France), E. Blanchard (Bordeaux, France), A. Parrot (Paris, France), F. Blanc (Nantes, France), A. Chabrol (Suresnes, France), S. Dominique (Rouen, France), A. Gibelin (Paris, France), A. Tazi (Paris, France), L. Berard (Paris, France), P. Brillet (Bobigny, France), M. Debray (Paris, France), A. Rousseau (Paris, France), M. Kerjouan (Rennes, France), O. Freynet (Bobgny, France), M. Dombret (Paris, France), A. Gamez (Montpellier, France), A. Nieves (Marseille, France), G. Beltramo (Dijon, France), J. Pastré (Paris, France), A. Le Borgne-Krams (Toulouse, France), T. Dégot (Strasbourg, France), C. Launois (Reims, France), L. Plantier (Tours, France), L. Wémeau-Stervinou (Lille, France), J. Cadranel (Paris, France), C. Chenivesse (Lille, France), D. Valeyre (Bobigny, France), B. Crestani (Paris, France), V. Cottin (Lyon, France), T. Simon (Paris, France), H. Nunes (Bobigny, France), On Behalf Of The Orphalung Network. RCT Abstract - Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomized, double-blind, placebo-controlled, phase 3 trial. 2903

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Azithromycin for the treatment of cough in idiopathic pulmonary fibrosis: A randomized controlled cross-over pilot trial.
Source: Virtual Congress 2020 – Chronic cough: only symptom or disease?
Year: 2020




A randomized, double-blind, placebo-controlled, phase III study of the safety and efficacy of interferon gamma-1b in patients with idiopathic pulmonary fibrosis
Source: Annual Congress 2007 - Clinical trial: new biological approaches to respiratory diseases
Year: 2007


RCT Abstract - Randomized, double-blind, placebo-controlled, phase III clinical trial with MV130, a sublingual bacterial immunotherapy to prevent COPD exacerbations
Source: Virtual Congress 2021 – ALERT: COPD
Year: 2021



Effects of a concomitant therapy with Cineole (Eucalyptole) on exacerbation rate in COPD: A placebo-controlled double-blind trial
Source: Annual Congress 2010 - COPD exacerbation
Year: 2010

Methotrexate in treatment of severe difficult-to-treat asthma: randomized, double-blind, placebo-controlled study
Source: Annual Congress 2007 - Towards controlling severe asthma
Year: 2007


Pulmonary vasodilator therapy in severe COPD: a double-blind, placebo-controlled trial
Source: Eur Respir J 2007; 30: Suppl. 51, 525s
Year: 2007

PRAISE, a randomized, placebo-controlled, double-blind Phase 2 clinical trial of pamrevlumab (FG-3019) in IPF patients
Source: International Congress 2017 – Idiopathic pulmonary fibrosis (IPF): treatment highlights
Year: 2017



A prospective randomised double-blind placebo controlled trial of venlafaxine in patients with stable chronic obstructive pulmonary disease (COPD)
Source: Eur Respir J 2006; 28: Suppl. 50, 32s
Year: 2006

Late Breaking Abstract - A randomised, double-blind, placebo controlled, clinical trial evaluating imatinib in patients with severe COVID-19
Source: Virtual Congress 2021 – Late breaking basic and translational science of SARS-Cov2 and COVID-19
Year: 2021



A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis
Source: Eur Respir J, 53 (3) 1801992; 10.1183/13993003.01992-2018
Year: 2019



Tiotropium treatment for bronchiectasis (ROBUST): a randomized, placebo-controlled, crossover trial
Source: International Congress 2017 – Bronchodilators and bronchoprotectors
Year: 2017


Azithromycin for treatment of hospitalised COVID-19 patients: a randomised, multicentre, open-label clinical trial (DAWn-AZITHRO)
Source: ERJ Open Res, 8 (1) 00610-2021; 10.1183/23120541.00610-2021
Year: 2022



A randomised, placebo-controlled trial of inhaled mannitol in patients with bronchiectasis
Source: Annual Congress 2008 - Infectious lung diseases including tuberculosis
Year: 2008


Late Breaking Abstract - First-time assessment of efficacy of candidate vaccine to prevent acute exacerbations of chronic obstructive pulmonary disease (AECOPD): multicentre, randomised, controlled, observer-blind phase 2b trial
Source: Virtual Congress 2021 – ALERT: COPD
Year: 2021



Macitentan for the treatment of idiopathic pulmonary fibrosis: the randomised controlled MUSIC trial
Source: Eur Respir J 2013; 42: 1622-1632
Year: 2013



The use of modafinil in patients with obstructive apnoea-hyponoea syndrome (OAHS). A randomized, placebo-controlled, double-blind study
Source: Eur Respir J 2001; 18: Suppl. 33, 419s
Year: 2001

High-dose versus low-dose prednisolone in symptomatic patients with post-COVID-19 diffuse parenchymal lung abnormalities: an open-label, randomised trial (the COLDSTER trial)
Source: Eur Respir J, 59 (2) 2102930; 10.1183/13993003.02930-2021
Year: 2022



Formoterol in patients with chronic obstructive pulmonary disease: a randomized, controlled, 3-month trial.
Source: Eur Respir J 2002; 20: 245
Year: 2002


A randomized, double-blind, placebo-controlled study to evaluate the role of formoterol in management of acute asthma
Source: Eur Respir J 2006; 28: Suppl. 50, 498s
Year: 2006