Late Breaking Abstract - Impact of the SARS-CoV-2 pandemic on incidence and phenotype of tuberculosis in a UK hotspot
J. Kim (Leicester, United Kingdom), R. Patel (Leicester, United Kingdom), D. Bell (Leicester, United Kingdom), M. Pareek (Leicester, United Kingdom), H. Thuraisingam (Leicester, United Kingdom), J. Lee (Leicester, United Kingdom), A. Gilmour-Caunt (Leicester, United Kingdom), L. Yorke (Leicester, United Kingdom), G. Woltmann (Leicester, United Kingdom), R. Verma (Leicester, United Kingdom), P. Haldar (Leicester, United Kingdom)
Source: Virtual Congress 2021 – Advances in treatment and management of tuberculosis and nontuberculous mycobacterial disease
Abstract Introduction The SARS-CoV-2 pandemic and response measures have significantly impacted healthcare delivery including tuberculosis (TB) services.
Aims To compare the incidence and phenotype of TB and latent TB infection rates in contacts between pre-pandemic (January 2019 – March 2020) and pandemic periods (April 2020 – March 2021) in Leicester, UK.
Methods Retrospective cohort study including all notified TB cases and contacts (January 2019 – March 2021).
Results 388 incident TB cases (179 pulmonary) were notified during the analysis period. Overall, the mean monthly number of TB cases was lower in the pandemic period (13.8 vs 14.9). For pulmonary TB (see table), patients were significantly younger, with an 88% increase in the proportion having smear positive disease. Median time to diagnosis after symptoms onset was 3 weeks lower during the pandemic, and driven by accelerated diagnosis in symptomatic patients presenting to hospital. There was a mean reduction of 1.1 and 0.5 contacts screened per smear negative and positive index case respectively, however a higher proportion screened with QuantiFERON-TB Gold Plus had latent TB infection (33% vs. 28%).
Conclusion Our data suggest the pandemic has disproportionately impacted presentation in older persons and smear negative pulmonary TB. As pandemic restrictions are eased, increased vigilance will be needed to prospectively sustain effective TB control.
Rating:
You must login to grade this presentation.
Share or cite this content
Citations should be made in the following way:
J. Kim (Leicester, United Kingdom), R. Patel (Leicester, United Kingdom), D. Bell (Leicester, United Kingdom), M. Pareek (Leicester, United Kingdom), H. Thuraisingam (Leicester, United Kingdom), J. Lee (Leicester, United Kingdom), A. Gilmour-Caunt (Leicester, United Kingdom), L. Yorke (Leicester, United Kingdom), G. Woltmann (Leicester, United Kingdom), R. Verma (Leicester, United Kingdom), P. Haldar (Leicester, United Kingdom). Late Breaking Abstract - Impact of the SARS-CoV-2 pandemic on incidence and phenotype of tuberculosis in a UK hotspot. 1608
You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.
Member's Comments
Related content which might interest you:
Related content which might interest you: