Donor-derived, cell-free DNA levels by next-generation targeted sequencing are elevated in allograft rejection after lung transplantation

Kiran K. Khush, Iwijn De Vlaminck, Helen Luikart, David J. Ross, Mark R. Nicolls

Source: ERJ Open Res, 7 (1) 00462-2020; 10.1183/23120541.00462-2020
Journal Issue: January

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Kiran K. Khush, Iwijn De Vlaminck, Helen Luikart, David J. Ross, Mark R. Nicolls. Donor-derived, cell-free DNA levels by next-generation targeted sequencing are elevated in allograft rejection after lung transplantation. ERJ Open Res, 7 (1) 00462-2020; 10.1183/23120541.00462-2020

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Multi-omics profiling predicts allograft function after lung transplantation
Source: Eur Respir J, 59 (2) 2003292; 10.1183/13993003.03292-2020
Year: 2022



Integrated mRNA and miRNA expression profiling of long-term survivors with normal allograft function after lung transplantation
Source: International Congress 2019 – Lung transplantation: from basic science to clinical outcomes
Year: 2019

Gene expression markers to segregate lung transplant rejection phenotypes
Source: International Congress 2017 – The ongoing struggle: insights into chronic lung allograft dysfunction (CLAD)
Year: 2017



Increased LIR-1 expression precedes serum cytomegalovirus detection and diagnosis of CMV disease in lung transplant recipients
Source: Eur Respir J 2002; 20: Suppl. 38, 347s
Year: 2002

Longitudinal assessment of CD4+CD25highCD69- treg cells in a cohort of lung transplant recipients (LTR). An association with chronic graft rejection
Source: Annual Congress 2008 - Donor organs and complications after lung transplantation
Year: 2008

Immunophenotype and gene signature of long-term survivors with normal allograft function after lung transplantation
Source: International Congress 2019 – Lung transplantation: from basic science to clinical outcomes
Year: 2019

Cytomegalovirus quantitative-PCR study in pulmonary tissue from lung transplant recipients
Source: Annual Congress 2010 - New clinical and experimental insights in lung transplantation
Year: 2010

Small airways function in allogeneic hematopoietic stem cell transplant recipients worsens over time and is correlated with change in chronic GVHD grade
Source: Annual Congress 2011 - Phenotyping and monitoring of airway diseases
Year: 2011

Specificities of the paediatric lung transplant recipient
Source: Annual Congress 2005 - PG9 - Long-term follow-up of lung transplant recipients
Year: 2005


TNFα-308 polymorphism associates with acute lung allograft rejection
Source: Eur Respir J 2005; 26: Suppl. 49, 175s
Year: 2005

NFkB location in T-cells is promising to monitor immunosuppression after lung transplantation
Source: International Congress 2014 – Post-transplant complications: from pathogenesis to treatment
Year: 2014

CMV management in lung transplant recipients
Source: School Course 2012 - Lung Transplantation
Year: 2012


T-cell response against tuberculosis antigens is dependent on the level of immunosuppression in renal and lung transplant patients
Source: Eur Respir J 2006; 28: Suppl. 50, 344s
Year: 2006

T cell analyses in blood, BAL and induced sputum from lung transplant recipients
Source: Annual Congress 2010 - Pre-operative evaluation and post-operative problems after lung transplantation
Year: 2010


KL-6 in serum as a biomarker for differentiation of chronic allograft dysfuntion in lung transplant. Preliminary results
Source: International Congress 2016 – Post-transplant complications: from animal models to the bedside
Year: 2016

Donor and recipient NOD2/CARD15 mutations associate with lung function decline following allogeneic stem cell transplantation
Source: Eur Respir J 2006; 28: Suppl. 50, 192s
Year: 2006

Basiliximab induction reduces the incidence of acute rejection in lung transplant patients
Source: International Congress 2018 – Moving lung transplantation forward
Year: 2018

Intragraft donor-specific antibodies and lung transplantation
Source: Eur Respir J, 54 (5) 1901937; 10.1183/13993003.01937-2019
Year: 2019



Differential gene expression of aquaporins (AQP) in lung transplant recipients with acute lung rejection.
Source: International Congress 2018 – Moving lung transplantation forward
Year: 2018


Strategies to increase limited donor resources
Source: Eur Respir J 2004; 23: 477-482
Year: 2004