Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity

Jonathan O'Loughlin, Robert J. Hall, Sangita Bhaker, Michael A. Portelli, Amanda Henry, Vincent Pang, David O. Bates, Tyson V. Sharp, Ian Sayers

Source: ERJ Open Res, 7 (1) 00254-2020; 10.1183/23120541.00254-2020
Journal Issue: January
Disease area: Airway diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Jonathan O'Loughlin, Robert J. Hall, Sangita Bhaker, Michael A. Portelli, Amanda Henry, Vincent Pang, David O. Bates, Tyson V. Sharp, Ian Sayers. Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity. ERJ Open Res, 7 (1) 00254-2020; 10.1183/23120541.00254-2020

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Changes in human airway cells transcriptome during epithelial wound repair
Source: Virtual Congress 2021 – Advanced in vitro models for drug discovery
Year: 2021


The epithelial integrity is preserved during particle exchange across the epithelium by macrophages and dendritic cells
Source: Annual Congress 2007 - Epithelial networks in the airways
Year: 2007


The epithelial integrity is preserved during particle exchange across the epithelium by macrophages and dendritic cells
Source: Eur Respir Rev 2008; 17: 78-80
Year: 2008



Induction of ontogenic pathways during differentiation of human bronchial epithelial cells in vitro
Source: Eur Respir J 2002; 20: Suppl. 38, 572s
Year: 2002

The role of basal cells in the aberrant repair of the epithelium in COPD
Source: International Congress 2017 – Lung tissue repair and remodelling in chronic lung diseases: mechanisms and therapeutic approaches
Year: 2017

Altered phenotype of COPD primary fibroblasts from airway and alveolar tissues: proliferation and apoptosis.
Source: International Congress 2019 – Research and innovation in airway diseases
Year: 2019

PTEN deficiency in alveolar type 2 cells accelerates cellular senescence, disrupts epithelial–mesenchymal and mitochondrial homeostasis, and induces age-related emphysema
Source: International Congress 2019 – Cellular metabolism and immune senescence in lung pathology
Year: 2019



Identification of transcripts overexpressed during airway epithelium differentiation
Source: Eur Respir J 2008; 32: 121-128
Year: 2008



Single cell RNA analysis of cellular niche in normal and impaired late lung development
Source: Virtual Congress 2020 – Airway development in health and disease
Year: 2020




TGFβ does not induce myofibroblast phenotype in primary human bronchial epithelial cells
Source: Annual Congress 2009 - Pathological remodelling in chronic lung disease: from epithelial-mesenchymal transition to cellular activation
Year: 2009


Human bronchial epithelial cells from patients with asthma have an altered gene expression profile
Source: ERJ Open Res, 8 (1) 00625-2021; 10.1183/23120541.00625-2021
Year: 2022



Impact of cellular composition on SARS-CoV-2 infection biology and pathogenesis in primary human airway epithelial cells
Source: Virtual Congress 2021 – Advanced in vitro models for drug discovery
Year: 2021


Diesel particle induces aging phenotype of bronchial epithelial cells via disruption of anti-aging molecule
Source: International Congress 2019 – Novel methods, diagnostics and biomarkers in chronic lung diseases
Year: 2019

Altered iron metabolism and elevated cellular senescence in COPD small airway epithelial cells
Source: Virtual Congress 2020 – Metabolic alterations and ageing in lung disease
Year: 2020




Aged alveolar epithelium contributes to inflammaging and reduced stem cell function in the lung
Source: Virtual Congress 2021 – Early manifestations of chronic respiratory disease: zooming in at the epithelial barrier
Year: 2021



LSC Abstract – Global gene expression analysis of the mucociliary differentiation process of human bronchial epithelial cells at the air-liquid interface
Source: International Congress 2016 – New genomic targets in pulmonary disease
Year: 2016


Role of autocrine factors produced by aiway basal cells in a 3D Organoid model testing bronchosphere generation which resembles epithelial remodeling processes in IPF
Source: International Congress 2019 – Intercellular communication in tissue remodelling of chronic lung diseases
Year: 2019



Altered pathways from alveolar epithelial cells
Source: ERS Research Seminar 2017 – Integrating systems biology approach in idiopathic pulmonary fibrosis research
Year: 2016

The role of the COPD susceptibility gene FAM13A in barrier function and pro-inflammatory responses of human airway epithelial cells
Source: ERS Lung Science Conference 2020
Year: 2020

Regulation of secretory component production in human bronchial epithelial cells by TGF-β
Source: Annual Congress 2008 - Airway cell biology
Year: 2008