RANKL contributes to lung tissue repair via promoting type II epithelial cell proliferation

H. Habibie (Groningen, Netherlands), S. Song (Groningen, Netherlands), K. Putri (Groningen, Netherlands), C. Boorsma (Groningen, Netherlands), R. Cool (Groningen, Netherlands), X. Wu (Groningen, Netherlands), R. Gosens (Groningen, Netherlands), Y. Wang (Groningen, Netherlands), W. Quax (Groningen, Netherlands), P. Olinga (Groningen, Netherlands), C. Brandsma (Groningen, Netherlands), W. Timens (Groningen, Netherlands), J. Burgess (Groningen, Netherlands), B. Melgert (Groningen, Netherlands)

Source: Virtual Congress 2020 – Elucidating the mechanisms underlying lung repair and exploring therapeutic strategies in vitro
Disease area: Airway diseases

Congress or journal article abstractWebcastSlide presentationE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
H. Habibie (Groningen, Netherlands), S. Song (Groningen, Netherlands), K. Putri (Groningen, Netherlands), C. Boorsma (Groningen, Netherlands), R. Cool (Groningen, Netherlands), X. Wu (Groningen, Netherlands), R. Gosens (Groningen, Netherlands), Y. Wang (Groningen, Netherlands), W. Quax (Groningen, Netherlands), P. Olinga (Groningen, Netherlands), C. Brandsma (Groningen, Netherlands), W. Timens (Groningen, Netherlands), J. Burgess (Groningen, Netherlands), B. Melgert (Groningen, Netherlands). RANKL contributes to lung tissue repair via promoting type II epithelial cell proliferation. 5029

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
PP126 – RANKL contributes to lung tissue repair via promoting type II epithelial cell proliferation
Source: ERS Lung Science Conference 2021
Year: 2021

Surface expression of CD74 by type II alveolar epithelial cells: a potential mechanism for macrophage migration inhibitory factor-induced epithelial repair
Source: Annual Congress 2008 - Border patrol: the alveolar barrier in lung injury
Year: 2008


Clara cells directly inhibit alveolar epithelial cell wound repair by inducing apoptosis
Source: Annual Congress 2010 - Novel insights into the pathophysiology of asthma and COPD
Year: 2010


GRX1 enhances wound repair of alveolar epithelial type II cells in vitro
Source: Annual Congress 2009 - Crossing the line: alveolo-capillary barrier control in acute lung injury
Year: 2009

Wnt11 inhibits epithelial-mesenchymal transition induced by TGFb1 in human type II alveolar epithelial cells
Source: Annual Congress 2012 - Fibrogenesis between epithelial injury and fibroblast proliferation
Year: 2012


Effect of hypoxia on gene regulation and differentiation in alveolar epithelial type II cells
Source: Eur Respir J 2001; 18: Suppl. 33, 162s
Year: 2001

PP207 – Targeting p16INK4a in alveolar type 2 cells to induce endogenous lung alveolar regeneration
Source: ERS Lung Science Conference 2021
Year: 2021

Lipoxin A4 promotes lung epithelial repair whilst inhibiting fibroblast proliferation
Source: ERJ Open Res 2016: 00079-2015
Year: 2016



Primary human airway epithelial cells inhibit proliferation of lung fibroblasts via transforming growth factor-β
Source: Annual Congress 2007 - Acute and chronic lung injury and its repair: novel molecular insight
Year: 2007


PTEN deficiency in alveolar type 2 cells accelerates cellular senescence, disrupts epithelial–mesenchymal and mitochondrial homeostasis, and induces age-related emphysema
Source: International Congress 2019 – Cellular metabolism and immune senescence in lung pathology
Year: 2019



Refractory remodelling of the microenvironment by type V collagen and apoptosis in non small cell lung cancer
Source: Annual Congress 2009 - Pathogenesis of lung cancer
Year: 2009



Nasal tolerance promotes increase in tumoral type V collagen protein synthesis and vascular apoptosis in the mouse lung chemical carcinogenesis
Source: Annual Congress 2010 - Novel cellular mechanisms in lung disease
Year: 2010


P2X7 receptor regulates cell survival, inflammation processes and proliferation of lung carcinoma cells
Source: International Congress 2019 – Novel insights from in vitro and in vivo models of lung disease
Year: 2019

Differential effects of collagen I and III and vitronectin on proliferation and apoptosis of human lung fibroblasts
Source: Eur Respir J 2004; 24: Suppl. 48, 105s
Year: 2004

The influence of stem cell supernatants on alveolar epithelial cell repair
Source: Eur Respir J 2007; 30: Suppl. 51, 719s
Year: 2007

MMP regulation of apoptosis via Fas-pathway in human airway epithelial cells
Source: Eur Respir J 2003; 22: Suppl. 45, 77s
Year: 2003

Assessment of the role of inflammatory cytokines in EMT and cell migration in alveolar epithelial cells
Source: Annual Congress 2009 - Airway cell biology
Year: 2009


In vitro profibrotic effects of rapamycin on basal or TGF-β1 induced primary human lung fibroblast: ECM production and turnover, migration and differentiation
Source: Annual Congress 2012 - Diffuse parenchymal lung disease I
Year: 2012

Upregulation of the production of TGF-β and IL-4 and downregulation of IL-6 by apoptotic human bronchial epithelial cells: possible role in regulation of epithelial repair following acute lung injury
Source: Eur Respir J 2001; 18: Suppl. 33, 477s
Year: 2001