Gefapixant does not have meaningful drug interactions with a MATE1/2K inhibitor or an OATP1B substrate

J. Nussbaum (South San Francisco, United States of America), J. Mccrea (West Point, United States of America), A. Hussain (West Point, United States of America), R. Evers (Rahway, United States of America), B. Ma (West Point, United States of America), J. Laabs (Lincoln, United States of America), C. Rillera (Las Vegas, United States of America), G. Garrett (Boston, United States of America), Y. Li (Rahway, United States of America), M. Vallee (West Point, United States of America), D. Panebianco (North Wales, United States of America), S. Stoch (Rahway, United States of America), M. Iwamoto (Rahway, United States of America)

Source: Virtual Congress 2020 – Chronic cough: only symptom or disease?
Session: Chronic cough: only symptom or disease?
Session type: Oral Presentation
Number: 4565
Disease area: Airway diseases

Congress or journal article abstractWebcastSlide presentationE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Nussbaum (South San Francisco, United States of America), J. Mccrea (West Point, United States of America), A. Hussain (West Point, United States of America), R. Evers (Rahway, United States of America), B. Ma (West Point, United States of America), J. Laabs (Lincoln, United States of America), C. Rillera (Las Vegas, United States of America), G. Garrett (Boston, United States of America), Y. Li (Rahway, United States of America), M. Vallee (West Point, United States of America), D. Panebianco (North Wales, United States of America), S. Stoch (Rahway, United States of America), M. Iwamoto (Rahway, United States of America). Gefapixant does not have meaningful drug interactions with a MATE1/2K inhibitor or an OATP1B substrate. 4565

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Pharmacological properties of a novel PI3Kd inhibitor, DS-1515
Source: International Congress 2018 – Basic pharmacology
Year: 2018


In vitro pharmacological characterization of the potent, lung selective pan-JAK inhibitor TD-8236
Source: International Congress 2019 – Advances in asthma pharmacology
Year: 2019


In vitro and in vivo pharmacological profile of RP6503, a novel dual PI3K Δ/gamma inhibitor, in pulmonary disease systems
Source: Annual Congress 2013 –Emerging new targets for the treatment of respiratory diseases
Year: 2013

Roflumilast N-oxide, a selective PDE4 inhibitor, curbs platelet-leukocyte interactions
Source: Annual Congress 2011 - Translational models of disease
Year: 2011


Identification of mechanism-specific biomarkers to guide development of the lung-selective inhaled pan-JAK inhibitor TD-8236
Source: Virtual Congress 2020 – Asthma science: novel targets and mechanisms
Year: 2020


NIK-626; a dual inhibitor of thromboxane synthase and 5-lipoxygenase, potential candidate as a novel anti-asthma compound
Source: Eur Respir J 2001; 18: Suppl. 33, 264s
Year: 2001

ADME properties of a novel PI3Kd inhibitor, DS-1515, in preclinical studies
Source: International Congress 2018 – Basic pharmacology
Year: 2018


Effect of CYP3A4 inhibitors verapamil and itraconazole on the pharmacokinetics of AZD7986, an oral DPP1 inhibitor
Source: International Congress 2017 – Asthma management
Year: 2017


In vivo pharmacological profile of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-α converting enzyme and matrix metalloproteinases, in models of airway inflammation
Source: Eur Respir J 2002; 20: Suppl. 38, 169s
Year: 2002

Molecular and cellular profile of the structurally novel phosphodiesterase (PDE) 4 inhibitor, BAY 19-8004
Source: Eur Respir J 2001; 18: Suppl. 33, 36s
Year: 2001

Human alpha-1 proteinase inhibitor (tal6004) manufacturing process and pathogen safety
Source: Annual Congress 2009 - Treatment of airways disease
Year: 2009


Pirfenidone, proton pump inhibitor, N acetyl cysteine (PINPOINT) therapy for IPF: Tolerance and safety profile among Indian patients
Source: Annual Congress 2012 - Diffuse parenchymal lung disease III
Year: 2012

Nonclinical safety profiles of DS-1515, a novel oral PI3Kd inhibitor.
Source: International Congress 2018 – Basic pharmacology
Year: 2018


Smoking has no effect on the pharmacokinetics of roflumilast, a new, orally active, selective PDE4 inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 156s
Year: 2001

Roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, is effective in the treatment of asthma
Source: Eur Respir J 2002; 20: Suppl. 38, 303s
Year: 2002

Late-breaking abstract: Pre-clinical characterization of RP3128, a novel and potent CRAC channel inhibitor for the treatment of respiratory disorders
Source: Annual Congress 2011 - Late-Breaking Abstracts Session: New treatments and targets for airway disease
Year: 2011


NIK-616, a new type of selective phosphodiesteraseIV(PDE IV) inhibitor with reduced emetic activity
Source: Eur Respir J 2001; 18: Suppl. 33, 35s
Year: 2001

In vitro pharmacological characterization of CHF6001, a novel selective phosphodiesterase 4 (PDE4) inhibitor with a robust anti-inflammatory profile
Source: International Congress 2014 – Novel targets and drugs for asthma and COPD
Year: 2014


PI3K inhibitor add-on strategy improve glucocorticoid insensitivity in severe asthma
Source: Virtual Congress 2020 – Asthma science: novel targets and mechanisms
Year: 2020

NIK-616,a new type of selective PDE IV inhibitor with reduced emetic activity
Source: Eur Respir J 2002; 20: Suppl. 38, 618s
Year: 2002