Interleukin-2 – induced vascular leak syndrome: clinically relevant in vitro recapitulation with a patient-derived lung-on-chip

G. Raggi (Bern, Switzerland), N. Roldan (Bern, Switzerland), V. Micallef (Basel, Switzerland), A. Rapet (Bern, Switzerland), L. De Maddalena (Bern, Switzerland), T. Imler (Bern, Switzerland), L. Froment (Bern, Switzerland), T. Marti (Bern, Switzerland), R. Schmid (Bern, Switzerland), E. Breous-Nystrom (Basel, Switzerland), A. Roth (Basel, Switzerland), L. Cabon (Basel, Switzerland), N. Hobi (Bern, Switzerland)

Source: Virtual Congress 2020 – Lung epithelial development and repair in three-dimensions
Session: Lung epithelial development and repair in three-dimensions
Session type: Oral Presentation
Number: 4326
Disease area: -

Congress or journal article abstractWebcastSlide presentationE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
G. Raggi (Bern, Switzerland), N. Roldan (Bern, Switzerland), V. Micallef (Basel, Switzerland), A. Rapet (Bern, Switzerland), L. De Maddalena (Bern, Switzerland), T. Imler (Bern, Switzerland), L. Froment (Bern, Switzerland), T. Marti (Bern, Switzerland), R. Schmid (Bern, Switzerland), E. Breous-Nystrom (Basel, Switzerland), A. Roth (Basel, Switzerland), L. Cabon (Basel, Switzerland), N. Hobi (Bern, Switzerland). Interleukin-2 – induced vascular leak syndrome: clinically relevant in vitro recapitulation with a patient-derived lung-on-chip. 4326

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Adapalene abrogates erlotinib-induced skin disorder by regulating proinflammatory cytokine production from human epidermal cells
Source: International Congress 2018 – Lung cancer: personalised medicine
Year: 2018




Late Breaking Abstract - Mesenchymal stromal cell exosomes prevent and revert experimental pulmonary fibrosis through systemic modulation of monocyte phenotypes
Source: International Congress 2018 – ILDs: From bench to bedside
Year: 2018




Extracellular ATP triggers and maintains airway inflammation in human and murine models of asthma by activating dendritic cells
Source: Annual Congress 2008 - New mechanisms in the pathogenesis of asthma and its response to treatment
Year: 2008


Reactivation of developmental pathways in idiopathic pulmonary fibrosis: FGF9 and FGF18 modulate the phenotype of control and fibrotic human lung fibroblasts in vitro
Source: International Congress 2015 – IPF: from bench to bedside
Year: 2015

Immunotherapy improves inflammatory response and lymphocyte apoptosis as a new therapeutic target in sepsis rat
Source: Annual Congress 2009 - Severe sepsis and multiple organ failure
Year: 2009


Human rhinovirus causes increase in angiogenetic activity of lung endothelial cells – potential involvement in enhanced vasculature in asthmatics
Source: Virtual Congress 2021 – Environmental and lifestyle impacts on chronic lung disease
Year: 2021

The COPD plasmatic microenvironment induces atrophy of healthy human myotubes in vitro
Source: International Congress 2017 – Best abstracts in the management of chronic respiratory diseases
Year: 2017

LSC Abstract – Role For IL-1alpha in viral-induced inflammatory responses in an epithelial-fibroblast co-culture model of the airway mucosa
Source: International Congress 2015 – Viral infections: basic research and clinical perspective
Year: 2015


Upregulation of the production of TGF-β and IL-4 and downregulation of IL-6 by apoptotic human bronchial epithelial cells: possible role in regulation of epithelial repair following acute lung injury
Source: Eur Respir J 2001; 18: Suppl. 33, 477s
Year: 2001

Activin-A is a critical inducer of human CD4+ICOS+IL-10-secreting regulatory T cells that suppress allergen-driven T cell responses in vitro and experimental asthma in a humanized mouse model in vivo
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

Fibroblast growth factors induce proliferation of cultured human airway smooth muscle cells: autocrine role in the pathogenesis of COPD
Source: Eur Respir J 2001; 18: Suppl. 33, 78s
Year: 2001

Extracellular vesicles derived from mesenchymal stem cells prevent pulmonary vascular dysfunction induced by lipopolysaccharide (LPS).
Source: International Congress 2018 – Experimental research in pulmonary hypertension
Year: 2018

BALF-derived fibroblasts differ from biopsy-derived fibroblasts in systemic sclerosis
Source: Eur Respir J 2007; 29: 446-452
Year: 2007



Characterization of human mesenchymal stem cells phenotype and secretome in a in vitro model of acute lung injury inflammation
Source: Annual Congress 2011 - Lung cell injury and repair
Year: 2011

Attenuation of human bronchial smooth muscle cell proliferation by rapamycin in Th2 cytokine dominant status
Source: Eur Respir J 2006; 28: Suppl. 50, 230s
Year: 2006

Functional changes in peripheral blood derived outgrowth endothelial progenitor cells from PAH patients in response to hypoxia
Source: International Congress 2018 – Pathobiology of pulmonary hypertension
Year: 2018



Peripheral blood Th17 and Th17/Th2 cells and their association with lung function and biomarkers in asthma-COPD overlap syndrome
Source: International Congress 2017 – Systemic and airway biomarkers
Year: 2017

Mesenchymal stem cell based angiopoietin-1 gene therapy for acute lung injury induced by lipopolysacharride in mice
Source: Annual Congress 2008 - Border patrol: the alveolar barrier in lung injury
Year: 2008

Circulating endothelial progenitor cells in patients with idiopathic pulmonary fibrosis (preliminary results)
Source: Annual Congress 2008 - Management of idiopathic pulmonary fibrosis: what can we learn from the pathophysiology?
Year: 2008


PAR-2 mediated interactions between mast cells and fibroblasts cause a switch in fibroblast morphology and cytokine profile
Source: International Congress 2019 – New mechanistic insights into pulmonary fibrosis
Year: 2019