Late Breaking Abstract - Use of ultra-low dose CT does not impact structure-function relationships in early Cystic Fibrosis lung disease
K. Bayfield (Sydney, Australia), O. Weinheimer (Heidelberg, Germany), C. Boyton (Sydney, Australia), R. Fitzpatrick (Sydney, Australia), A. Middleton (Sydney, Australia), B. Kennedy (Sydney, Australia), A. Blaxland (Sydney, Australia), G. Jayasuriya (Sydney, Australia), N. Caplain (Sydney, Australia), M. Wielpuetz (Heidelberg, Germany), L. Yu (Minneosota, United States of America), C. Galban (Michigan, United States of America), T. Robinson (Stanford, United States of America), B. Bartholmai (Minneosota, United States of America), P. Gustafsson (Skövde, Sweden), D. Fitzgerald (Sydney, Australia), H. Selvadurai (Sydney, Australia), P. Robinson (Sydney, Australia)
Source: Virtual Congress 2020 – New frontiers in cystic fibrosis imaging and lung physiology
Disease area: -
Abstract Introduction Impact of ultra-low-dose (ULD) computed tomography (CT) on quantification of structural disease and structure-function relationships in early Cystic Fibrosis (CF) lung disease have not been studied to date.
Aim To quantify structural lung disease and compare same session standard low radiation dose (LD) and ULD CT with pulmonary function measures in early CF lung disease.
Methods 46 CF subjects (age 11(6-17) yrs) with mild lung disease (FEV1 =70%pred) performed multiple breath washout (MBW), and spirometry directed paired inspiratory/expiratory CT with LD (CTDIvol: 1.23 mGy) and ULD (CTDIvol: 0.22 mGy). Quantification was performed automatically by validated institutional CT software.
Results Effective radiation dose was reduced by 78% in ULD vs. LD. Rates of abnormality were highest for CT and MBW and lowest for spirometry. Strong correlations were observed between LD and ULD readouts (gas trapping r=0.91, p<0.001). A consistently positive offset was observed for gas trapping in ULD vs. LD (7.5% greater with ULD, p<0.0001).
Abnormality (%)
FEV1
LCI
Scond
Sacin
FEV1
0
-
-0.38^
-0.34^
-0.28
LCI
72
-
-
0.80*
0.57*
Scond
77
-
-
-
0.43^
Sacin
48
-
-
-
-
Bronchiectasis LD
23
-0.31
0.48^
0.50^
0.45*
Gas Trapping LD
100
-0.45^
0.70*
0.71*
0.37^
Bronchiectasis ULD
15
-0.11
0.59*
0.50*
0.59*
Gas Trapping ULD
100
-0.47^
0.62*
0.69*
0.37^
Values are Pearson's r unless stated,^ p<0.05, * p<0.001
Conclusions Excellent correlations, yet significant differences in quantitative metrics were observed between LD and ULD CT. Good and preserved structure-function relationships with ULD support its use for quantitative CT in order to reduce radiation dose in CF populations.
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K. Bayfield (Sydney, Australia), O. Weinheimer (Heidelberg, Germany), C. Boyton (Sydney, Australia), R. Fitzpatrick (Sydney, Australia), A. Middleton (Sydney, Australia), B. Kennedy (Sydney, Australia), A. Blaxland (Sydney, Australia), G. Jayasuriya (Sydney, Australia), N. Caplain (Sydney, Australia), M. Wielpuetz (Heidelberg, Germany), L. Yu (Minneosota, United States of America), C. Galban (Michigan, United States of America), T. Robinson (Stanford, United States of America), B. Bartholmai (Minneosota, United States of America), P. Gustafsson (Skövde, Sweden), D. Fitzgerald (Sydney, Australia), H. Selvadurai (Sydney, Australia), P. Robinson (Sydney, Australia). Late Breaking Abstract - Use of ultra-low dose CT does not impact structure-function relationships in early Cystic Fibrosis lung disease. 4310
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