Clinical characteristics of adult obese asthma with type-2 inflammation dominant
M. To (Koshigaya, Japan), R. Tsuzuki (Tokyo, Japan), S. Yamawaki (Tokyo, Japan), N. Honda (Koshigaya, Japan), I. Kano (Koshigaya, Japan), K. Haruki (Koshigaya, Japan), Y. To (Tokyo, Japan)
Source: Virtual Congress 2020 – Clinical characteristics and diagnostic tools for phenotyping asthma and COPD
Disease area: Airway diseases
Abstract [RATIONALE] In adult asthma, obesity-related non-eosinophilic asthma has been identified as a phenotype of asthma, which is characterized by late-onset, female predominance, and an increased frequency of severe symptoms. However, in a clinical setting, some adult asthmatic patients with obesity have eosinophilia and/or specific allergen sensitization. This study aimed to investigate the clinical characteristics of adult obese asthma with type-2 inflammation dominant and to establish the two potential phenotypes of adult obese asthma.
[METHODS] Adult asthmatic patients (Age=20yr) with obesity were enrolled in this study. The patients were classified into two groups according to type 2 inflammation dominant (eosinophil counts=300/mL and/or a specific allergen is detected, T2) or non-type 2 inflammation dominant (NT2), and clinical parameters were compared between the groups.
[RESULTS] A total of 434 patients (351 in T2 and 83 in NT2) were enrolled. Age and duration of asthma in T2 were significantly lower and longer than those in NT2, respectively. A higher and lower percentage of patients in T2 had a history of childhood asthma and aspirin sensitivity, respectively. Multivariate logistic regression analysis showed that T2 was independently associated with younger age, longer duration of asthma, history of childhood asthma and less aspirin sensitivity.
[CONCLUSION] Two phenotypes of adult asthmatic patients with obesity are detected. One is characterized by non-type 2 inflammation dominant and a relatively higher percentage of aspirin sensitivity, and another is characterized by type 2 inflammation dominant, longer duration of asthma and a higher percentage of history of childhood asthma.
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M. To (Koshigaya, Japan), R. Tsuzuki (Tokyo, Japan), S. Yamawaki (Tokyo, Japan), N. Honda (Koshigaya, Japan), I. Kano (Koshigaya, Japan), K. Haruki (Koshigaya, Japan), Y. To (Tokyo, Japan). Clinical characteristics of adult obese asthma with type-2 inflammation dominant. 192
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