Exercise training in people following surgery for non-small cell lung cancer: a Cochrane systematic review
V. Cavalheri (Perth, Australia), C. Burtin (Diepenbeek, Belgium), V. Formico (Presidente Prudente, Brazil), M. Nonoyama (Oshawa, Canada), S. Jenkins (Perth, Australia), M. Spruit (Horn, Netherlands), K. Hill (Perth, Australia)
Source: International Congress 2019 – Insights into rehabilitation and physical activity of patients with respiratory disease
Disease area: -
Abstract Introduction: Impairments in several health-related outcomes are common in people following surgery for non-small cell lung cancer (NSCLC). This review is an update of our 2013 Cochrane systematic review on the effects of postoperative exercise training on health-related outcomes in this population.
Aim: To determine the effects of exercise training on exercise capacity, health-related quality of life (HRQoL), muscle force and symptoms in people following surgery for NSCLC.
Method: We searched CENTRAL, MEDLINE, EMBASE, SciELO and PEDro up to Feb 2019. Randomised controlled trials (RCTs) in which people with NSCLC, following surgery, were allocated to receive either exercise training or no exercise training were included. Two authors independently screened/identified the studies for inclusion. Meta-analyses were performed.
Results: A total of eight RCTs on 450 participants (180 [40%] females) were included. On completion of the intervention period, exercise capacity was greater in the exercise group (peak rate of oxygen uptake: mean difference (MD) [95% confidence interval (CI)] 3.1 [2.0; 4.2]mL/kg/min; 6-minute walk distance: 54 [25; 84]m). The exercise group also had greater improvements in the physical component of general HRQoL (5.0 [2.3; 7.7] points), quadriceps muscle force (standardised mean difference (SMD) [95% CI] 0.75 [0.4; 1.1]), and reported less dyspnoea (SMD [95% CI] -0.43 [-0.81; -0.05]). The effect observed on the mental component of general HRQoL, disease-specific HRQoL and the other outcomes was uncertain (95% CIs traversed 0).
Conclusion: This systematic review highlights the importance of exercise training in the postoperative management of people with NSCLC.
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V. Cavalheri (Perth, Australia), C. Burtin (Diepenbeek, Belgium), V. Formico (Presidente Prudente, Brazil), M. Nonoyama (Oshawa, Canada), S. Jenkins (Perth, Australia), M. Spruit (Horn, Netherlands), K. Hill (Perth, Australia). Exercise training in people following surgery for non-small cell lung cancer: a Cochrane systematic review. 5358
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