Hedgehog pathway activation is altered in COPD patients

R. Belgacemi (Reims, France), J. Ancel (Reims, France), J. Perotin (Reims, France), E. Luczka (Reims, France), A. Germain (Reims, France), G. Delepine (Reims, France), X. Dubernard (Reims, France), J. Mérol (Reims, France), M. Polette (Reims, France), G. Deslée (Reims, France), V. Dormoy (Reims, France)

Source: International Congress 2019 – Cellular responses and cell therapy in lung injury and repair
Session: Cellular responses and cell therapy in lung injury and repair
Session type: Poster Discussion
Number: 3867
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
R. Belgacemi (Reims, France), J. Ancel (Reims, France), J. Perotin (Reims, France), E. Luczka (Reims, France), A. Germain (Reims, France), G. Delepine (Reims, France), X. Dubernard (Reims, France), J. Mérol (Reims, France), M. Polette (Reims, France), G. Deslée (Reims, France), V. Dormoy (Reims, France). Hedgehog pathway activation is altered in COPD patients. 3867

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Analysis of cytokine signaling pathway JAK-STAT through their activation in patients with asthma
Source: Annual Congress 2008 - Novel mechanisms and targets of molecular pulmonary pathology
Year: 2008


Notch pathway signaling in asthma
Source: Annual Congress 2006 - Markers of paediatric airway disease
Year: 2006


Increased pulmonary Wnt signaling in patients with sarcoidosis
Source: Annual Congress 2007 - Interstitial lung disease: diagnostic and therapeutic novelties
Year: 2007


Inhibition of VEGF blocks the activation of TGF-β1 through a PI3K/Akt signaling pathway in allergic airway disease of mice
Source: Annual Congress 2007 - Current issues in airway physiology, pharmacology and monitoring
Year: 2007


Role of RhoA/Rho-kinase pathway in the regulation of eNOS activity in COPD patients
Source: Annual Congress 2010 - Pathobiology of pulmonary hypertension
Year: 2010


Activation of the inflammasome pathway during exacerbations of COPD
Source: Annual Congress 2011 - Recent developments in COPD
Year: 2011


Involvement of Hedgehog pathway in airway cell differentiation
Source: International Congress 2018 – New kids on the block: novel molecular pathways and therapeutic targets in chronic lung diseases
Year: 2018




Activation of IL-32 pathway in COPD
Source: Annual Congress 2008 - Cell biology of asthma and COPD
Year: 2008

The KEAP1/NRF2 signaling system genes and theirs target genes are associated with COPD
Source: International Congress 2018 – Functional genomics and COPD: new challenges
Year: 2018


Activation of TGFβ/Smad signalling pathway in induced sputum of asthmatic children
Source: Annual Congress 2009 - Novel mechanisms in the pathogenesis of asthma
Year: 2009

Decreased Wnt/β-catenin signaling in COPD: Possible involvement of Wnt antagonists
Source: Annual Congress 2012 - New mechanisms in non-neoplastic and neoplastic lung diseases
Year: 2012

NTPDase1/CD39 and aberrant purinergic signalling in the pathogenesis of COPD
Source: Eur Respir J 2016; 47: 254-263
Year: 2016



Targeting the mTOR signaling pathway to inhibit lung cell senescence in chronic obstructive pulmonary disease (COPD)
Source: ERS Lung Science Conference 2017
Year: 2017

Temporal analysis of the intracellular signaling pathways involved in Th17/Treg response in COPD development
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of COPD
Year: 2019


Wnt and TGF-beta signaling in lung development
Source: Lung Science Conference 2009 - Cell proliferation, Differentiation and Carcinogenesis
Year: 2009



Involvement of the Hedgehog signalling pathway in idiopathic pulmonary fibrosis
Source: Annual Congress 2011 - Growth factors and fibrogenesis: are they good, bad or both?
Year: 2011

Hedgehog signalling crosstalks orchestrate human lung development
Source: Virtual Congress 2020 – Cellular stress in respiratory diseases
Year: 2020


In addition to mTOR and JAK/STAT, NLRP3 inflammasome is another key pathway activated in sarcoidosis
Source: Eur Respir J, 55 (3) 2000149; 10.1183/13993003.00149-2020
Year: 2020



Genetic variations in the TLR signaling pathway are associated with childhood asthma
Source: Annual Congress 2012 - Asthma and the genes: from GWAS to next generation transcriptome analyses
Year: 2012

BMP-Smad1 target gene Wnt inhibitory factor 1 (WIF1) coordinates BMP and Wnt signaling activities in regulating lung development in vivo
Source: Annual Congress 2010 - New mechanisms in lung development, acute and chronic lung diseases
Year: 2010