Ablation of ADAM17 protects against cigarette smoke-induced emphysema in mice

S. Suzuki (Tokyo, Japan), M. Ishii (Tokyo, Japan), T. Asakura (Tokyo, Japan), H. Namkoong (Tokyo, Japan), S. Okamori (Tokyo, Japan), K. Yagi (Tokyo, Japan), H. Kamata (Tokyo, Japan), T. Kusumoto (Tokyo, Japan), S. Kagawa (Tokyo, Japan), A. Hegab (Tokyo, Japan), K. Horiuchi (Tokyo, Japan), N. Hasegawa (Tokyo, Japan), T. Betsuyaku (Tokyo, Japan)

Source: International Congress 2019 – Effects of environmental exposures in lung pathology and the underlying mechanisms
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
S. Suzuki (Tokyo, Japan), M. Ishii (Tokyo, Japan), T. Asakura (Tokyo, Japan), H. Namkoong (Tokyo, Japan), S. Okamori (Tokyo, Japan), K. Yagi (Tokyo, Japan), H. Kamata (Tokyo, Japan), T. Kusumoto (Tokyo, Japan), S. Kagawa (Tokyo, Japan), A. Hegab (Tokyo, Japan), K. Horiuchi (Tokyo, Japan), N. Hasegawa (Tokyo, Japan), T. Betsuyaku (Tokyo, Japan). Ablation of ADAM17 protects against cigarette smoke-induced emphysema in mice. 2400

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Caspase-7 knockout mice are not protected against cigarette smoke-induced inflammation
Source: Annual Congress 2010 - Novel mechanisms in COPD
Year: 2010


Deficiency in neutrophil serine proteases protects mice from the development of cigarette smoke-induced emphysema
Source: Annual Congress 2010 - Proteases and the matrix
Year: 2010

Role of ß2-adrenergic receptor in cigarette smoke-induced COPD in mice
Source: International Congress 2018 – Functional genomics and COPD: new challenges
Year: 2018

Attenuation of lung inflammation and emphysema induced by cigarette smoke exposure in CXCR3 knockout mice
Source: Annual Congress 2008 - Cell biology of asthma and COPD
Year: 2008


Mitochondria-targeted H2S suppresses and reverses cigarette smoke-induced inflammasome activity and lung injury in experimental COPD
Source: ERS Lung Science Conference 2020
Year: 2020

Irisin secreted from muscle by exercise ameliorates emphysema of cigarette smoke-induced COPD in mice.
Source: International Congress 2019 – New molecular signatures in COPD, lung cancer and a1-antitrypsin deficiency
Year: 2019


Cigarette smoke-induced emphysema occurs in the absence of TLR4-signalling in a murine model of COPD
Source: Annual Congress 2008 - Best of lung epithelial cells 2008
Year: 2008



Propolis reverts cigarette smoke-induced emphysema through macrophage alternative activation
Source: International Congress 2017 – From the bench: therapeutic approaches in COPD and emphysema
Year: 2017


Role of activin-A in cigarette smoke-induced inflammation and COPD
Source: Eur Respir J 2014; 43: 1028-1041
Year: 2014



Oral presentation: SOD3 protects cigarette smoke-induced emphysema associated with reduction of extracellular matrix fragmentation in mice
Source: Lung Science Conference 2010 - Biology of gene-environment interactions in the lung
Year: 2010

Disruption of pulmonary lipid homeostasis drives cigarette smoke-induced lung inflammation in mice
Source: Eur Respir J 2015; 46: 1451-1460
Year: 2015



LATE-BREAKING ABSTRACT: BRP-39 contribute to cigarette smoke-induced inflammation and emphysema in mice and humans
Source: Annual Congress 2009 - Airway cell biology
Year: 2009


Transgenic expression of human glutathione peroxidase-1 prevents cigarette smoke-induced inflammation and emphysema formation in mice
Source: Eur Respir J 2007; 30: Suppl. 51, 133s
Year: 2007

P2RX4 signalling enhances acute cigarette smoke-induced lung inflammation and chronic lung emphysema development
Source: International Congress 2019 – Airway inflammation: pharmacological mechanisms and novel targets
Year: 2019


PDE4 inhibition prevents corticosteroid-resistant lung inflammation induced by cigarette smoke exposure in mice
Source: Annual Congress 2009 - Highlighting the epithelial cell in lung disease: from COPD to cancer to acute lung injury
Year: 2009


RAGE and cigarette smoke-induced pulmonary lesions: a chronic study on genetically manipulated mice
Source: Annual Congress 2009 - From emphysema to fibrosis: mechanisms of cellular remodelling in the diseased lung
Year: 2009

Tiotropium inhalation prevents acute cigarette smoke-induced airway inflammation in mice
Source: Annual Congress 2009 - Airway inflammation and host defence
Year: 2009

Ceramide-1-phosphate inhibits cigarette smoke-induced airway inflammation
Source: Eur Respir J 2015; 45: 1669-1680
Year: 2015



The role of microRNA-155 in cigarette smoke-induced inflammation.
Source: International Congress 2018 – New kids on the block: novel molecular pathways and therapeutic targets in chronic lung diseases
Year: 2018



Lack of RTP801, a suppressor of the mTOR pathway, attenuates cigarette smoke-induced pulmonary injuries in mice
Source: Eur Respir J 2007; 30: Suppl. 51, 140s
Year: 2007