Heparin Binding Protein in sputum compromises epithelial defence and relates to bronchiectasis severity

A. Smith (Dundee, United Kingdom), J. Lang (Dundee, United Kingdom), H. Keir (Dundee, United Kingdom), S. Finch (Dundee, United Kingdom), S. Aliberti (Milan, Italy), O. Sibila (Barcelona, Spain), A. Shoemark (Dundee, United Kingdom), J. Chalmers (Dundee, United Kingdom)

Source: International Congress 2019 – Clinical and translational studies of bronchiectasis and non-TB mycobacterial infection
Disease area: Airway diseases, Respiratory infections

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Smith (Dundee, United Kingdom), J. Lang (Dundee, United Kingdom), H. Keir (Dundee, United Kingdom), S. Finch (Dundee, United Kingdom), S. Aliberti (Milan, Italy), O. Sibila (Barcelona, Spain), A. Shoemark (Dundee, United Kingdom), J. Chalmers (Dundee, United Kingdom). Heparin Binding Protein in sputum compromises epithelial defence and relates to bronchiectasis severity. 2172

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Induced sputum and respiratory function in pulmonary fybrosis
Source: Eur Respir J 2003; 22: Suppl. 45, 178s
Year: 2003

Smoking alters alpha1-antitrypsin in alveolar macrophages possibly promoting misfolding
Source: International Congress 2014 – New studies into pulmonary proteases and antiproteases
Year: 2014

Cell composition of induced sputum in patients with uncontrolled asthma and its participation in the formation of cold airway hyperresponsiveness
Source: Annual Congress 2013 –Phenotyping asthma: clinical severity, comorbid conditions response to treatment?
Year: 2013


Late Breaking Abstract - A GATA3-specific DNAzyme attenuates sputum eosinophilia in COPD patients with eosinophilic airway inflammation
Source: International Congress 2017 – Update and new perspectives in Airway Diseases
Year: 2017

The role of circulating mitochondrial DNA in modulating airway inflammation of chronic obstructive pulmonary disease
Source: International Congress 2014 – Cell biology 2014
Year: 2014

Inhibition of uPA-uPAR signaling restores respiratory epithelial barrier function in asthma and COPD
Source: International Congress 2019 – Cellular responses and cell therapy in lung injury and repair
Year: 2019

Mucosal inflammation in idiopathic bronchiectasis: cellular and molecular mechanisms
Source: Eur Respir J 2008; 31: 396-406
Year: 2008



Comparison of inflammatory markers in induced and spontaneous sputum in COPD patients
Source: International Congress 2014 – Translational studies in COPD
Year: 2014

Expression of MMP-8 protein in alveolar macrophages is related to bronchial asthma severity and treatment efficacy
Source: Annual Congress 2010 - Cell biology and immunology of lung disease
Year: 2010

Mild pH alteration leads to intracellular retention of IL-8 by airway epithelial cells
Source: Annual Congress 2013 –The pulmonary epithelium: recent developments
Year: 2013


Conduct of a biomarker study in bronchiectasis patients: Correlation of neutrophil elastase activity and inflammatory load in induced sputum
Source: International Congress 2014 – Systemic and airway biomarkers
Year: 2014

Induced sputum in asthma and COPD: meassuring type and inflammation activity
Source: Eur Respir J 2003; 22: Suppl. 45, 76s
Year: 2003

Altered protein homeostasis in pulmonary fibrosis indicates a role for proteasomal activator 200
Source: International Congress 2014 – New and old players in fibrotic lung disease
Year: 2014

Cytokine regulation of the chronicle inflammation of bronchial asthma patients
Source: Eur Respir J 2005; 26: Suppl. 49, 590s
Year: 2005

Sputum neutrophil differential cell count in health and relationship to disease severity in asthma
Source: International Congress 2014 – Phenotyping and monitoring asthma and COPD
Year: 2014


Enhanced inflammatory gene expression in bronchial epithelial cells from asthmatic patients: Attenuation by a Brd4 mimic
Source: International Congress 2014 – Novel targets and drugs for asthma and COPD
Year: 2014


Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function
Source: Annual Congress 2008 - Mechanisms of respiratory infections: interaction between the pathogen and the host
Year: 2008


Bacterial exacerbation of COPD: assessment of neutrophil activation in induced sputum
Source: Annual Congress 2004 - Role of infection in COPD
Year: 2004


Induced sputum to assess bronchial inflammation in children with intermittent athopic asthma
Source: Eur Respir J 2003; 22: Suppl. 45, 399s
Year: 2003