Late Breaking Abstract - High-content phenotypic profiling reveals that IL-13 impairs planar cell polarity and directional mucus clearance in human airway tissue

D. Roth (Vienna, Austria), R. Villenave (Boston, United States of America), A. Van Der Does (Leiden, Netherlands), P. Hiemstra (Leiden, Netherlands), J. Nawroth (Boston, United States of America)

Source: International Congress 2019 – Understanding lung disease: novel in vitro models
Session: Understanding lung disease: novel in vitro models
Session type: Oral Presentation
Number: 1898
Disease area: Airway diseases

Congress or journal article abstractWebcastSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
D. Roth (Vienna, Austria), R. Villenave (Boston, United States of America), A. Van Der Does (Leiden, Netherlands), P. Hiemstra (Leiden, Netherlands), J. Nawroth (Boston, United States of America). Late Breaking Abstract - High-content phenotypic profiling reveals that IL-13 impairs planar cell polarity and directional mucus clearance in human airway tissue. 1898

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Gene expression changes in human bronchial epithelial cells in response to leukotriene E4
Source: International Congress 2015 – Translational research in respiratory care: new findings
Year: 2015

Leukotriene E4 affects expression of genes involved in inflammatory, remodelling and mitogenic responses in human bronchial epithelial cells
Source: International Congress 2016 – Novel insights into alveolar and bronchial epithelial cell injury and repair
Year: 2016

LSC Abstract – Global gene expression analysis of the mucociliary differentiation process of human bronchial epithelial cells at the air-liquid interface
Source: International Congress 2016 – New genomic targets in pulmonary disease
Year: 2016


Late Breaking Abstract - Assessment of a ciliary transport protein in airway cells reveals novel pattern in cystic fibrosis
Source: International Congress 2017 – Cystic fibrosis: clinical issues
Year: 2017


Late Breaking Abstract: Alveolar epithelial function in mouse lungs: A novel real-time measurement of barrier properties
Source: Annual Congress 2010 - Novel insights into the pathophysiology of asthma and COPD
Year: 2010

High dimensional single cell analysis reveals unexpected immune cell types, and loss of motility and chemokine receptor expression of alveolar macrophages in chronic obstructive respiratory disease
Source: International Congress 2018 – Advanced profiling of immune cells in chronic lung diseases
Year: 2018



Late Breaking Abstract - WNT/ß-catenin signaling induces cellular senescence in lung alveolar epithelial cells
Source: International Congress 2019 – Oxidative stress, hypoxia and microbial exposure in the pathogenesis of pulmonary disease
Year: 2019

Single-cell RNA sequencing reveals novel cell differentiation dynamics in the human airway epithelium
Source: International Congress 2019 – The Human Lung Cell Atlas
Year: 2019


The capacity of human airway epithelium to regulate T cell proliferation is reduced in asthma
Source: International Congress 2015 – Asthma mechanisms and management
Year: 2015

Global gene expression analyses highlight the role of plasma membrane remodeling as a molecular functions of airway epithelium in response to interleukin-13 treatment
Source: International Congress 2015 – Promising novel findings in translational pulmonary research
Year: 2015


Human mast cells and type 2 innate lymphoid cells activate gene expression and mucus composition in human bronchial epithelial cells via IL-13
Source: International Congress 2014 – Mechanistic studies of the airway epithelium
Year: 2014

Late Breaking Abstract - Spatial pharmacokinetics of inhaled drugs in human lung – evaluation of regional lung targeting by direct sampling of epithelial lining fluid
Source: International Congress 2019 – New towards old therapies in airway diseases
Year: 2019



Novel cell types and altered cell states in asthma revealed by single-cell RNA sequencing of airway wall biopsies.
Source: International Congress 2018 – A fresh view on airway differentiation and regeneration
Year: 2018



LSC Abstract – High mobility group box 1 modulates lung innate immunity by promoting wound healing and cytokine release in human bronchial epithelial cells
Source: International Congress 2015 – Airway remodelling: recent developments
Year: 2015

Optimization of Human Lung-Chip cultures to investigate effects of biomechanics on primary airway epithelial cell biology
Source: Virtual Congress 2020 – Lung epithelial development and repair in three-dimensions
Year: 2020




Late Breaking Abstract - Role of ß-catenin and Notch signalling in increased airway mucous cell differentiation in asthma
Source: International Congress 2019 – Molecular and experimental paediatric lung disease
Year: 2019



Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity
Source: ERJ Open Res, 7 (1) 00254-2020; 10.1183/23120541.00254-2020
Year: 2021



Human airway epithelial cell stimulation causes IL-8 expression via a PKC-TACE-EGFR-MEK pathway
Source: Annual Congress 2005 - Inflammation and remodelling in allergy and asthma
Year: 2005


Late Breaking Abstract - Loss of PTEN induces alveolar epithelial cell senescence resulting in lung fibrosis via activated NF-?B
Source: International Congress 2018 – ILDs: From bench to bedside
Year: 2018



Human lung mast cells alter asthmatic airway epithelial cell function
Source: Annual Congress 2013 –The pulmonary epithelium: recent developments
Year: 2013