The cross-talk between TGF-ß and periostin can be targeted for pulmonary fibrosis

Y. Nanri (SAGA, Japan), S. Nunomura (SAGA, Japan), Y. Terasaki (Tokyo, Japan), T. Yoshihara (SAGA, Japan), Y. Hirano (SAGA, Japan), Y. Yokozaki (Hiroshima, Japan), K. Ajito (Yokohama, Japan), S. Murakami (Yokohama, Japan), S. Conway (Indianapolis, Indiana, United States of America), K. Izuhara (SAGA, Japan)

Source: International Congress 2019 – Translational aspects of idiopathic interstitial pneumonia
Session: Translational aspects of idiopathic interstitial pneumonia
Session type: Thematic Poster
Number: 1292
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Y. Nanri (SAGA, Japan), S. Nunomura (SAGA, Japan), Y. Terasaki (Tokyo, Japan), T. Yoshihara (SAGA, Japan), Y. Hirano (SAGA, Japan), Y. Yokozaki (Hiroshima, Japan), K. Ajito (Yokohama, Japan), S. Murakami (Yokohama, Japan), S. Conway (Indianapolis, Indiana, United States of America), K. Izuhara (SAGA, Japan). The cross-talk between TGF-ß and periostin can be targeted for pulmonary fibrosis. 1292

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
HSP47siRNA targeting to myofibroblasts attenuates bleomycin-induced pulmonary fibrosis
Source: Annual Congress 2012 - Interstitial lung disease: from bench to bedside
Year: 2012

VEGF expression does not differentiate between idiopathic pulmonary fibrosis and pulmonary sarcoidosis
Source: Eur Respir J 2007; 30: Suppl. 51, 574s
Year: 2007

Upregulation of Fas-signalling molecules in lung epithelial cells from patients with idiopathic pulmonary fibrosis
Source: Eur Respir J 2001; 17: 180-189
Year: 2001



Expression of Smad proteins during myofibroblast differentiation in pulmonary fibrosis
Source: Eur Respir J 2005; 26: Suppl. 49, 267s
Year: 2005

VEGF gene transfer enhances fibrosis but improves pulmonary hemodynamics in experimental pulmonary fibrosis
Source: Annual Congress 2008 - Animal models of pulmonary fibrosis: mechanisms and therapies
Year: 2008

Increased fibrinolytic mediators in IPF as potential contributors to pulmonary fibrosis and vascular remodeling
Source: International Congress 2015 – IPF: from bench to bedside
Year: 2015

PP121 – Gaq/11 and Ga12/13 promote pulmonary fibrosis by driving distinct myofibroblast functions
Source: ERS Lung Science Conference 2021
Year: 2021

The lung epithelium is a prominent source of Wnt ligands and inhibitors in idiopathic pulmonary fibrosis
Source: Annual Congress 2008 - Vascular and interstitial remodelling in chronic lung disease: therapeutic interventions on the horizon
Year: 2008

Tranilast inhibits pulmonary fibrosis by suppressing TGFbeta-mediated extracellular matrix protein production
Source: Annual Congress 2013 –Diffuse pulmonary fibrosis
Year: 2013

Reactivation of developmental pathways in idiopathic pulmonary fibrosis: FGF9 and FGF18 modulate the phenotype of control and fibrotic human lung fibroblasts in vitro
Source: International Congress 2015 – IPF: from bench to bedside
Year: 2015

Molecular mechanisms of lung tissue remodeling in progression of idiopathic pulmonary fibrosis
Source: Annual Congress 2010 - Emerging mechanisms in lung injury
Year: 2010

IL-11 promotes pulmonary vascular remodeling and lung fibrosis through the activation of endothelial to mesenchymal transition.
Source: Virtual Congress 2020 – Translational aspects of idiopathic pulmonary fibrosis
Year: 2020

High expression of telomerase/endothelin-1 increase replication and activation of vascular myofibroblasts in usual interstitial pneumonia/idiopathic pulmonary fibrosis
Source: Annual Congress 2010 - Pathogenesis of diffuse parenchymal lung disease
Year: 2010


RhoA signalling influences cyclin D1 expression and associated fibroblast turnover: implications for idiopathic pulmonary fibrosis (IPF)
Source: Annual Congress 2006 - Lung vascular and parenchymal remodeling
Year: 2006


Nintedanib inhibits contractile activity of lung myofibroblasts in a cellular model of scleroderma associated pulmonary fibrosis
Source: International Congress 2018 – CTD-ILD and hypersensitivity pneumonitis: from the bench to the bedside
Year: 2018




The increased contractility of idiopathic pulmonary fibrosis lung fibroblasts is dependent on angiotensin signalling
Source: Annual Congress 2010 - Pathogenesis of diffuse parenchymal lung disease
Year: 2010

The role of expression of TLR 4 in bleomycin-induced pulmonary fibrosis in mice
Source: Annual Congress 2013 –The role of hormones and cytokines in lung injury
Year: 2013


Role of endothelin in lung fibrosis
Source: Eur Respir Rev 2008; 17: 145-150
Year: 2008



The dysregulation of E-cadherin contributes to pulmonary emphysema
Source: International Congress 2017 – Insight into the pathogenesis of emphysema and pneumonia
Year: 2017