Selective activation and targeting of autophagy in severe asthma.

K. Mcalinden (Sydney, Australia), A. Kota (Sydney, Australia), B. Oliver (Sydney, Australia), M. Haghi (Sydney, Australia), P. Sharma (Sydney, Australia)

Source: International Congress 2018 – Preclinical pharmacology: novel targets in airway inflammation, narrowing and neural control
Disease area: Airway diseases

Congress or journal article abstractWebcastSlide presentationE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. Mcalinden (Sydney, Australia), A. Kota (Sydney, Australia), B. Oliver (Sydney, Australia), M. Haghi (Sydney, Australia), P. Sharma (Sydney, Australia). Selective activation and targeting of autophagy in severe asthma.. 5251

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Induced sputum differential gene expression implicates increased p38 signalling activity in severe asthma
Source: Annual Congress 2011 - Molecular: pathology of infectious and inflammatory lung disease
Year: 2011


Selective decoy-mediated inhibition of activator protein-1 activity in the airways prevents experimental asthmatic inflammation
Source: Annual Congress 2005 - Regulation of the allergic and asthmatic response
Year: 2005


Inhibition of VEGF blocks the activation of TGF-β1 through a PI3K/Akt signaling pathway in allergic airway disease of mice
Source: Annual Congress 2007 - Current issues in airway physiology, pharmacology and monitoring
Year: 2007


Inhibition of uPA-uPAR signaling restores respiratory epithelial barrier function in asthma and COPD
Source: International Congress 2019 – Cellular responses and cell therapy in lung injury and repair
Year: 2019

Dual mechanism of action of T2 inhibitor therapies in virally induced exacerbations of asthma: evidence for a beneficial counter-regulation
Source: Eur Respir J, 54 (1) 1802390; 10.1183/13993003.02390-2018
Year: 2019



Targeting the mTOR signaling pathway to inhibit lung cell senescence in chronic obstructive pulmonary disease (COPD)
Source: ERS Lung Science Conference 2017
Year: 2017

Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma
Source: Eur Respir J 2010; 35: 750-756
Year: 2010



Inhibition of the alternative complement pathway abolishes the development of airway hyperresponsiveness (AHR) and inflammation
Source: Eur Respir J 2004; 24: Suppl. 48, 348s
Year: 2004

Nrf2-regulated chaperon-mediated autophagy is involved in apoptosis modulation in COPD pathogenesis.
Source: Virtual Congress 2020 – Cellular stress in respiratory diseases
Year: 2020


Chaperone-mediated autophagy modulates epithelial cell apoptosis in COPD pathogenesis.
Source: International Congress 2019 – Effects of environmental exposures in lung pathology and the underlying mechanisms
Year: 2019

TGFβ overproduction in asthma reduces the epithelial repair by down-regulating the leptin/leptin receptor pathway
Source: Eur Respir J 2007; 30: Suppl. 51, 59s
Year: 2007

Anti-inflammatory effect of hypoxic signaling suppression in the severe COPD model.
Source: International Congress 2018 – COPD: novel pathological mechanisms in the airway epithelium
Year: 2018


A role for WNT-5B in airway remodeling in COPD by activation of TGF-beta/Smad3 signaling?
Source: Annual Congress 2013 –COPD: experimental biology
Year: 2013

Treatment with Omalizumab in adults with severe allergic reduces Fc?I expression on dendritic cells and improves antiviral responses.
Source: International Congress 2019 – Understanding, monitoring and targeting severe asthma
Year: 2019

Inhibition of Pim1 kinase, new therapeutic approach in virus-induced asthma exacerbations
Source: Eur Respir J 2016; 47: 783-791
Year: 2016



Rapamycin protects OVA induced asthma in mice through regulating autophagy
Source: International Congress 2015 – Exploring mechanisms in obstructive airway diseases
Year: 2015

Oxidative stress-induced corticosteroid insensitivity is reversed by formoterol via inhibition of PI3K signalling in peripheral blood mononuclear cells from patients with COPD and severe asthma
Source: Annual Congress 2011 - Models of disease and drug actions
Year: 2011

Inhibition of phosphodiesterase 4B enhances glucocorticoid-dependent gene transcription in human airway epithelial cells: Implications for the treatment of COPD
Source: Annual Congress 2013 –New drugs in respiratory medicine
Year: 2013


Cigarette-decreased NAD/SIRT1 aggravates pulmonary fibrosis by promoting senescence of alveolar type 2 cells through autophagy inhibition and mitochondrial oxidative stress induction
Source: Virtual Congress 2020 – Idiopathic pulmonary fibrosis and interstitial lung disease: progression, genes and more
Year: 2020

Dual aVß6/aVß1 inhibitor PLN-74809 blocks multiple TGF-ß activation pathways associated with IPF
Source: International Congress 2019 – Translational aspects of idiopathic interstitial pneumonia
Year: 2019